ANTIPYRETIC, ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF CERTAIN γ-OXOBUTANOIC ACID DERIVATIVES

被引：0
|
作者：
Khaled A. Abouzid
Khairia M. Youssef
Amany A. E. Ahmed
Hanaa Hussain Al-Zuhair
机构：
[1] Ain Shams University,Department of Pharaceutical Chemistry
[2] King Saud University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[3] King Saud University,Department of Pharmacology, Faculty of Pharmacy
来源：
Medicinal Chemistry Research | 2005年 / 14卷
关键词：
Celecoxib; Acid Derivative; Open Ring; Chemical Entity; Fenbufen;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Three chemical entities were synthesized as analogs of fenbufen as well as open ring analog of suldinac and celecoxib. The new compounds were evaluated for antipyretic, antinociceptive and anti-inflammatory activities. Among these compounds, 6-benzo[1,3]dioxol-5-yl-4-oxo-hex-5-enoic acid (3) was the most active one.
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页码：26 / 39
页数：13
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