Development of the Composition and Technology for Controlled-Release Lornoxicam Tablets

The influence of several factors on the release kinetics of lornoxicam and methyluracil from hydrophilic matrices was investigated. These included the type of prolonging polymer, its relative content, the ratio of lactose monohydrate and microcrystalline cellulose, and the composition and concentration of granulating solution. Cellulose derivatives such as hydroxyethylcellulose and sodium carboxymethylcellulose and polymers based on vinylpyrrolidone (Kollidon SR, Kollidon VA-64) were used as the polymers modifying the release. The optimum controlled-release lornoxicam tablet composition was found and contained 8 – 15% hydroxyethylcellulose and 8 – 15% Kollidon VA-64, which was added to the tablet mixture as a moisturizer, and 30 – 40% each of lactose monohydrate and microcrystalline cellulose. The resulting composition of lornoxicam tablets released evenly the active ingredient over 8 h. The degree of lornoxicam release after 4 h was 60 ± 5%; after 8 h, >95%.