Thermal studies of isoniazid and mixtures with rifampicin

被引：0
|
作者：
Fátima Duarte Freire
Cícero Flávio Soares Aragão
Túlio Flávio Accioly de Lima e Moura
Fernanda Nervo Raffin
机构：
[1] Universidade Federal Do Rio Grande Do Norte – UFRN,Laboratório de Desenvolvimento de Medicamentos, Programa de Pós
[2] NUPLAM – Núcleo de Pesquisa em Alimentos e Medicamentos,Graduação em Ciências Farmacêuticas, Departamento de Farmácia
[3] Universidade Federal do Rio Grande do Norte – UFRN,Laboratório de Controle de Qualidade de Medicamentos, Programa de Pós
来源：
Journal of Thermal Analysis and Calorimetry | 2009年 / 97卷
关键词：
Drug development; Isoniazid; Rifampicin;
D O I：
暂无
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摘要：
Rifampicin–Isoniazid mixture is a frequently used product in the treatment of tuberculosis. Rifampicin exhibits polymorphism and exists in two polymorphic forms: the stable form I and the metastable form II. The aim of this work was to evaluate the thermal behavior of the binary mixtures of polymorphs I and II of rifampicin and isoniazid by using DSC. Mixtures of different forms (rifampicin form I and II) showed interaction with isoniazid indicating that the mixtures are less stable compared to the drug alone. Interaction was observed in case of both polymorphs of rifampicin.
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页码：333 / 336
页数：3
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