Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis

被引：0
|
作者：
T Hamaki
H Katori
M Kami
T Yamato
H Yamakado
T Itoh
E Kusumi
M Igarashi
J Ueyama
Y Kanda
S Miyakoshi
S Mineishi
S Morinaga
M Mukai
M Hayashi
Y Takaue
S Hara
Y Mutou
机构：
[1] Toranomon Hospital,Department of Hematology
[2] Toranomon Hospital,Department of Nephrology
[3] Toranomon Hospital,Department of Pharmacology
[4] Hematopoietic Stem Cell Transplant Unit,Department of Clinical Immunology and Hematology
[5] National Cancer Center Hospital,undefined
[6] Sapporo City General Hospital,undefined
来源：
Bone Marrow Transplantation | 2002年 / 30卷
关键词：
aplastic anemia; chronic renal failure; melphalan; reduced intensity conditioning; hemodialysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.
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页码：195 / 198
页数：3
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