Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry

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作者
Rodrigo R. R. Duarte
Dennis C. Copertino
Luis P. Iñiguez
Jez L. Marston
Yaron Bram
Yuling Han
Robert E. Schwartz
Shuibing Chen
Douglas F. Nixon
Timothy R. Powell
机构
[1] Weill Cornell Medicine,Division of Infectious Diseases, Department of Medicine
[2] Cornell University,Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience
[3] King’s College London,Division of Gastroenterology and Hepatology, Department of Medicine
[4] Weill Cornell Medicine,Department of Surgery, Weill Cornell Medicine
[5] Cornell University,Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine
[6] Cornell University,undefined
[7] Cornell University,undefined
来源
Molecular Medicine | 2021年 / 27卷
关键词
Drug repositioning; Lung organoids; Pandemic; COVID-19; Connectivity mapping; Chemoinformatics; Molecular docking; Drug screening; Drug testing; Atorvastatin;
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