Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry

被引：0
|
作者：
Rodrigo R. R. Duarte
Dennis C. Copertino
Luis P. Iñiguez
Jez L. Marston
Yaron Bram
Yuling Han
Robert E. Schwartz
Shuibing Chen
Douglas F. Nixon
Timothy R. Powell
机构：
[1] Weill Cornell Medicine,Division of Infectious Diseases, Department of Medicine
[2] Cornell University,Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience
[3] King’s College London,Division of Gastroenterology and Hepatology, Department of Medicine
[4] Weill Cornell Medicine,Department of Surgery, Weill Cornell Medicine
[5] Cornell University,Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine
[6] Cornell University,undefined
[7] Cornell University,undefined
来源：
Molecular Medicine | 2021年 / 27卷
关键词：
Drug repositioning; Lung organoids; Pandemic; COVID-19; Connectivity mapping; Chemoinformatics; Molecular docking; Drug screening; Drug testing; Atorvastatin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry
    Duarte, Rodrigo R. R.
    Copertino, Dennis C., Jr.
    Iniguez, Luis P.
    Marston, Jez L.
    Bram, Yaron
    Han, Yuling
    Schwartz, Robert E.
    Chen, Shuibing
    Nixon, Douglas F.
    Powell, Timothy R.
    MOLECULAR MEDICINE, 2021, 27 (01)
  • [2] Repurposing drug molecule against SARS-Cov-2 (COVID-19) through molecular docking and dynamics: a quick approach to pick FDA-approved drugs
    Farhat, Nabeela
    Khan, Asad U.
    JOURNAL OF MOLECULAR MODELING, 2021, 27 (11)
  • [3] Repurposing drug molecule against SARS-Cov-2 (COVID-19) through molecular docking and dynamics: a quick approach to pick FDA-approved drugs
    Nabeela Farhat
    Asad U. Khan
    Journal of Molecular Modeling, 2021, 27
  • [4] FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy
    Drozdzal, Sylwester
    Rosik, Jakub
    Lechowicz, Kacper
    Machaj, Filip
    Kotfis, Katarzyna
    Ghavami, Saeid
    Los, Marek J.
    DRUG RESISTANCE UPDATES, 2020, 53
  • [5] Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets
    Park, Su-Jin
    Yu, Kwang-Min
    Kim, Young-Il
    Kim, Se-Mi
    Kim, Eun-Ha
    Kim, Seong-Gyu
    Kim, Eun Ji
    Casel, Mark Anthony B.
    Rollon, Rare
    Jang, Seung-Gyu
    Lee, Min-Hyeok
    Chang, Jae-Hyung
    Song, Min-Suk
    Jeong, Hye Won
    Choi, Younho
    Chen, Weiqiang
    Shin, Woo-Jin
    Jung, Jae U.
    Choi, Young Ki
    MBIO, 2020, 11 (03):
  • [6] Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
    Ko, Meehyun
    Jeon, Sangeun
    Ryu, Wang-Shick
    Kim, Seungtaek
    JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (03) : 1403 - 1408
  • [7] Repurposing FDA-approved drugs against multiple proteins of SARS-CoV-2: An in silico study
    Akinlalu, Alfred Olaoluwa
    Chamundi, Annapoorna
    Yakumbur, Donald Terseer
    Afolayan, Funmilayo I. Deborah
    Duru, Ijeoma Akunna
    Arowosegbe, Michael Aderibigbe
    Enejoh, Ojochenemi Aladi
    SCIENTIFIC AFRICAN, 2021, 13
  • [8] Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
    Jeon, Sangeun
    Ko, Meehyun
    Lee, Jihye
    Choi, Inhee
    Byun, Soo Young
    Park, Soonju
    Shum, David
    Kim, Seungtaek
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 64 (07)
  • [9] Candidate drugs against SARS-CoV-2 and COVID-19
    McKee, Dwight L.
    Sternberg, Ariane
    Stange, Ulrike
    Laufer, Stefan
    Naujokat, Cord
    PHARMACOLOGICAL RESEARCH, 2020, 157
  • [10] Identification and Assessment of FDA-Approved Drugs for Repurposing as Single and Combination Therapies Against SARS-CoV-2 Infection
    Pacl, H. T.
    Tipper, J. L.
    Holder, G. D.
    Sevalkar, R. R.
    Nadeem, S.
    Chinta, K. C.
    Crouse, A.
    Steyn, A. J. C.
    Might, M.
    Harrod, K. S.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 203 (09)
12345