Defect of Tumour Necrosis Factor-α (TNF-α) Production and TNF-α-induced ICAM-1 – Expression in BRCA1 Mutations Carriers

被引：0
|
作者：
Christoph C. Zielinski
Alexandra C. Budinsky
Teresa M.U. Wagner
Roswitha M. Wolfram
Wolfgang J. Köstler
Marion Kubista
Thomas Brodowicz
Ernst Kubista
Christoph Wiltschke
机构：
[1] University Hospital,Clinical Division of Oncology, Department of Medicine I
[2] Ludwig Boltzmann Institute for Clinical Experimental Oncology,Clinical Division of Special Gynaecology, Department of Obstetrics and Gynaecology
[3] University Hospital,Clinical Division of Angiology, Department of Medicine II
[4] University Hospital,undefined
来源：
Breast Cancer Research and Treatment | 2003年 / 81卷
关键词：
BRCA1; breast cancer; germline; tumour necrosis factor-α;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background. Tumour necrosis factor-α (TNF-α) is a potent cytokine secreted primarily by activated cells from the monocyte/macrophage lineage which exhibits various antitumoral effects including the induction of apoptosis, necrosis, activation of lytic effector cells as well as upregulation of the expression of intercellular adhesion molecule-1 (ICAM-1) which is of decisive importance in the interaction with lymphokine activated killer cells. Previous studies from our laboratory have indicated impaired production of TNF-α by monocytes as well as decreased expression of ICAM-1 on monocytes derived from patients with various stages of breast cancer.
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页码：99 / 105
页数：6
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