Real-time acoustic elastic property monitoring of compacts during compaction

被引：0

作者：

Akseli I. ^{[1
]}

Libordi C. ^{[1
]}

Cetinkaya C. ^{[1
]}

机构：

[1] Department of Mechanical and Aeronautical Engineering, Center for Advanced Materials Processing, Clarkson University, Potsdam

来源：

Journal of Pharmaceutical Innovation | 2008年 / 3卷 / 2期

基金：

美国国家科学基金会;

关键词：

Acoustic monitoring techniques; Acoustic ultrasonic measurements; Drug tablet monitoring; Powder compaction; Process analytical technology; Real-time compaction monitoring; Tablet elastic properties;

D O I：

10.1007/s12247-008-9029-z

中图分类号：

学科分类号：

摘要：

A nondestructive, real-time acoustic technique for determining elastic properties of compacts during compaction is presented. An acoustic time-of-flight study was conducted, and the extraction of the linear elastic properties of calcium carbonate compacts was demonstrated. To verify the results of the acoustic experiments, a uniaxial compaction investigation was also carried out using a computer-controlled press with an instrumented die. Good agreement between linear elastic properties determined using both acoustic experiments and compaction force-displacement data was observed. This technique has the potential to be used as a real-time compaction monitoring tool. © International Society for Pharmaceutical Engineering 2008.

引用

页码：134 / 140

页数：6

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