Neuroprotective Effects of Dibornol in Focal Cerebral Ischemia/Reperfusion in Rats

被引：0
|
作者：
G. A. Chenysheva
V. A. Smol’akova
A. V. Kutchin
I. Yu. Chukicheva
M. B. Plotnikov
机构：
[1] Russian Academy of Sciences,E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
[2] Ural Division of the Russian Academy of Sciences,Institute of Chemistry, Komi Research Center
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 166卷
关键词：
2,6-diisobornyl-4-methylphenol; focal cerebral ischemia/reperfusion; survival rate; neurological deficit; Wistar rats;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Neuroprotective activity of 2,6-diisobornyl-4-methylphenol (Dibornol) was studied under conditions of experimental focal cerebral ischemia/reperfusion modeled by intraluminal occlusion of the left middle cerebral artery for 1 h followed by recirculation. Dibornol administered in a dose of 10 mg/kg intragastrically 24 h and 30 min before and 24 h after focal ischemia/reperfusion modeling reduced the size of the brain infarction zone by 52% (48 h after recirculation) and neurological deficit by 1.7-2.4 times in comparison with that in control animals.
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页码：15 / 18
页数：3
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