Safety and efficacy of everolimus in Chinese patients with metastatic renal cell carcinoma resistant to vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapy: an open-label phase 1b study

被引:0
|
作者
Jun Guo
Yiran Huang
Xu Zhang
Fangjian Zhou
Yinghao Sun
Shukui Qin
Zhangqun Ye
Hui Wang
Annette Jappe
Patrick Straub
Nicoletta Pirotta
Sven Gogov
机构
[1] Peking University Cancer Hospital and Institute,
[2] Shanghai Renji Hospital,undefined
[3] The General Hospital of PLA,undefined
[4] Sun Yat-sen University Cancer Center,undefined
[5] Shanghai Changhai Hospital,undefined
[6] Nanjing Bayi Hospital,undefined
[7] Wuhan Tongji Hospital,undefined
[8] Beijing Novartis Pharma Company,undefined
[9] Ltd.,undefined
[10] Novartis Pharma AG,undefined
[11] Novartis Pharma AG,undefined
[12] Novartis Pharma AG,undefined
[13] Novartis Pharma AG,undefined
来源
BMC Cancer | / 13卷
关键词
Asian; Everolimus; mTOR inhibitor; Renal cell cancer; Sunitinib; Sorafenib;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Efficacy and safety of sequential use of everolimus in Japanese patients with advanced renal cell carcinoma after failure of first-line treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitor: a multicenter phase II clinical trial
    Oyama, Masafumi
    Sugiyama, Takayuki
    Nozawa, Masahiro
    Fujimoto, Kiyohide
    Kishida, Takeshi
    Kimura, Go
    Tokuda, Noriaki
    Hinotsu, Shiro
    Shimozuma, Kojiro
    Akaza, Hideyuki
    Ozono, Seiichiro
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 47 (06) : 551 - 559
  • [32] Final results of the international, expanded-access program of everolimus in patients with advanced renal cell carcinoma who progress after prior vascular endothelial growth factor receptor-tyrosine kinase inhibitor (VEGFr-TKI) therapy.
    Gruenwald, V.
    Karakiewicz, P. I.
    Bavbek, S. E.
    Miller, K.
    Machiels, J. H.
    Lee, S.
    Larkin, J. M. G.
    Bono, P.
    Rha, S. Y.
    Castellano, D. E.
    Blank, C. U.
    Knox, J. J.
    Hawkins, R.
    Yuan, R. R.
    Rosamilia, M.
    Booth, J. L.
    Bodrogi, I.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
  • [33] Prognostic tissue biomarker exploration for patients with metastatic renal cell carcinoma receiving vascular endothelial growth factor receptor tyrosine kinase inhibitors
    Park, Inkeun
    Cho, Yong Mee
    Lee, Jae-Lyun
    Ahn, Jin-Hee
    Lee, Dae-Ho
    TUMOR BIOLOGY, 2016, 37 (04) : 4919 - 4927
  • [34] Activity of axitinib in patients with metastatic renal cell carcinoma previously treated with both vascular endothelial growth factor receptor tyrosine-kinase inhibitor and mammalian target of rapamycin inhibitor
    Mizuno, Ryuichi
    Miyajima, Akira
    Oya, Mototsugu
    INTERNATIONAL JOURNAL OF UROLOGY, 2014, 21 (07) : 740 - 740
  • [35] Pharmacokinetics, Safety, and Preliminary Efficacy of Oral Trifluridine/Tipiracil in Chinese Patients with Solid Tumors: A Phase 1b, Open-Label Study
    Wang, Xicheng
    Zhou, Jianfeng
    Li, Yan
    Ge, Yuping
    Zhou, Yanping
    Bai, Chunmei
    Shen, Lin
    CLINICAL PHARMACOLOGY-ADVANCES AND APPLICATIONS, 2020, 12 : 21 - 33
  • [36] Efficacy and safety of endothelial growth factor receptor (VEGFR)-tyrosine kinase inhibitors (TKI) after programmed cell death 1 (PD-1) inhibitor treatment in patients with metastatic clear cell renal cell carcinoma (mccRCC).
    Nadal, Rosa
    Amin, Asim
    Geynisman, Daniel M.
    Voss, Martin Henner
    Weinstock, Matthew
    Doyle, Jaime
    Zhang, Zhe
    Viudez, Antonio
    Plimack, Elizabeth R.
    McDermott, David F.
    Motzer, Robert
    Rini, Brian I.
    Hammers, Hans J.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [37] DTRMWXHS-12, a novel Bruton tyrosine kinase inhibitor, in combination with everolimus and pomalidomide in patients with relapsed/refractory lymphomas: An open-label, multicenter, phase 1a/1b study
    Huntington, Scott F.
    Schuster, Stephen J.
    Ding, Wei
    Koehler, Amber B.
    Brander, Danielle M.
    Rosenthal, Allison C.
    Leis, Jose F.
    Tun, Han W.
    Moustafa, Muhamad Alhaj
    Iqbal, Madiha
    He, Wei
    Kearney, Albert S.
    McKinlay, Timothy P.
    Gui, Min
    Mato, Anthony R.
    AMERICAN JOURNAL OF HEMATOLOGY, 2023, 98 (05) : 739 - 749
  • [38] Efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors for Chinese patients with squamous cell carcinoma of lung harboring EGFR mutation
    Fang, Wenfeng
    Zhang, Jianwei
    Liang, Wenhua
    Huang, Yan
    Yan, Yue
    Wu, Xuan
    Hu, Zhihuang
    Ma, Yuxiang
    Zhao, Hongyun
    Zhao, Yuanyuan
    Yang, Yunpeng
    Xue, Cong
    Zhang, Jing
    Zhang, Li
    JOURNAL OF THORACIC DISEASE, 2013, 5 (05) : 585 - 592
  • [39] Nodular Regenerative Hyperplasia of the Liver Associated With Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor in a Patient With Metastatic Renal Cell Carcinoma
    Rudolph, Shannon
    Li, Mingjia
    Gheeya, Jinesh
    Zimmerman, Danielle
    Yin, Ming
    Clinton, Steven K.
    Parwani, Anil V.
    Yang, Yuanquan
    JCO PRECISION ONCOLOGY, 2023, 7
  • [40] Analysis of Anti-Angiogenesis-Related Adverse Events Associated with Vascular Endothelial Growth Factor Receptor-Tyrosine Kinase Inhibitors (VEGFR-TKIs) in Patients with Metastatic Renal Cell Carcinoma
    Lee, Nuri
    Lee, Jae Lyun
    Lee, Ju-Yeun
    TARGETED ONCOLOGY, 2023, 18 (02) : 247 - 255