Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

被引:0
|
作者
Sara Lovisa
Valerie S LeBleu
Björn Tampe
Hikaru Sugimoto
Komal Vadnagara
Julienne L Carstens
Chia-Chin Wu
Yohannes Hagos
Birgitta C Burckhardt
Tsvetelina Pentcheva-Hoang
Hersharan Nischal
James P Allison
Michael Zeisberg
Raghu Kalluri
机构
[1] Metastasis Research Center,Department of Cancer Biology
[2] University of Texas M.D. Anderson Cancer Center,Department of Nephrology and Rheumatology
[3] Göttingen University Medical Center,Department of Genomic Medicine
[4] Georg August University,Department of Immunology
[5] University of Texas M.D. Anderson Cancer Center,undefined
[6] Institute of Systemic Physiology and Pathophysiology,undefined
[7] Göttingen University Medical Center,undefined
[8] Georg August University,undefined
[9] University of Texas M.D. Anderson Cancer Center,undefined
来源
Nature Medicine | 2015年 / 21卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
During renal fibrosis epithelial cells undergo a partial epithelial-to-mesenchymal transition that can be targeted to reverse established disease.
引用
收藏
页码:998 / 1009
页数:11
相关论文
共 50 条
  • [1] Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
    Lovisa, Sara
    LeBleu, Valerie S.
    Tampe, Bjorn
    Sugimoto, Hikaru
    Vadnagara, Komal
    Carstens, Julienne L.
    Wu, Chia-Chin
    Hagos, Yohannes
    Burckhardt, Birgitta C.
    Pentcheva-Hoang, Tsvetelina
    Nischal, Hersharan
    Allison, James P.
    Zeisberg, Michael
    Kalluri, Raghu
    NATURE MEDICINE, 2015, 21 (09) : 998 - +
  • [2] The role of epithelial-to-mesenchymal transition in renal fibrosis
    Michael Zeisberg
    Raghu Kalluri
    Journal of Molecular Medicine, 2004, 82 : 175 - 181
  • [3] The role of epithelial-to-mesenchymal transition in renal fibrosis
    Zeisberg, M
    Kalluri, R
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2004, 82 (03): : 175 - 181
  • [4] The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition
    Fedorova, Larisa V.
    Raju, Vanamala
    El-Okdi, Nasser
    Shidyak, Amjad
    Kennedy, David J.
    Vetteth, Sandeep
    Giovannucci, David R.
    Bagrov, Alexei Y.
    Fedorova, Olga V.
    Shapiro, Joseph I.
    Malhotra, Deepak
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2009, 296 (04) : F922 - F934
  • [5] GDF11 induces kidney fibrosis, renal cell epithelial-to-mesenchymal transition, and kidney dysfunction and failure
    Pons, Marianne
    Koniaris, Leonidas G.
    Moe, Sharon M.
    Gutierrez, Juan C.
    Esquela-Kerscher, Aurora
    Zimmers, Teresa A.
    SURGERY, 2018, 164 (02) : 262 - 273
  • [6] Hyperoxia induces alveolar epithelial-to-mesenchymal cell transition
    Vyas-Read, Shilpa
    Wang, Wenyi
    Kato, Satomi
    Colvocoresses-Dodds, Jennifer
    Fifadara, Nimita H.
    Gauthier, Theresa W.
    Helms, My N.
    Carlton, David P.
    Brown, Lou Ann S.
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2014, 306 (04) : L326 - L340
  • [7] EPITHELIAL-TO-MESENCHYMAL TRANSITION AND LUNG FIBROSIS
    Tam, A.
    Sonnylal, S.
    Leask, A.
    Denton, C. P.
    de Crombrugghe, B.
    Norman, J.
    Abraham, D. J.
    RHEUMATOLOGY, 2012, 51 : 123 - 123
  • [8] Characterization and Role of SCAI during Renal Fibrosis and Epithelial-to-Mesenchymal Transition
    Fintha, Attila
    Gasparics, Akos
    Fang, Lilla
    Erdei, Zsuzsa
    Hamar, Peter
    Mozes, Miklos M.
    Koekeny, Gabor
    Rosivall, Laszlo
    Sebe, Attila
    AMERICAN JOURNAL OF PATHOLOGY, 2013, 182 (02): : 388 - 400
  • [9] Epithelial-to-Mesenchymal Transition in Renal Neoplasms
    He, Huiying
    Magi-Galluzzi, Cristina
    ADVANCES IN ANATOMIC PATHOLOGY, 2014, 21 (03) : 174 - 180
  • [10] Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition
    Skibba, Melissa
    Khan, Md. Abdul Hye
    Kolb, Lauren L.
    Yeboah, Michael M.
    Falck, John R.
    Amaradhi, Radhika
    Imig, John D.
    FRONTIERS IN PHARMACOLOGY, 2017, 8