Administration of Aggregated Beta-Amyloid Peptide (25–35) Induces Changes in Long-Term Potentiation in the Hippocampus in Vivo

被引：36

作者：

V. V. Trubetskaya

M. Yu. Stepanichev

M. V. Onufriev

N. A. Lazareva

V. A. Markevich

N. V. Gulyaeva

机构：

[1] Institute of Higher Nervous Activity and Neurophysiology,

[2] Russian Academy of Sciences,undefined

来源：

Neuroscience and Behavioral Physiology | 2003年 / 33卷 / 2期

关键词：

Peptide; Oxidative Stress; Protein Fragment; Stable Increase; Intracerebroventricular Administration;

D O I：

10.1023/A:1021761310435

中图分类号：

学科分类号：

摘要：

Intracerebroventricular administration of aggregated β-amyloid protein fragment (25–35) (7.5 nmol/ventricle) was followed one month later by significant changes in the dynamics of long-term potentiation in the hippocampus in vivo, expressed as powerful and stable increases in the amplitude of evoked potentials. This phenomenon may be associated with oxidative stress in the hippocampus, which has previously been demonstrated in this model, and, thus, with disturbances in ion homeostasis.

引用

页码：95 / 98

页数：3

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