Neurofibrillary pathology in the human paraventricular and supraoptic nuclei

被引：0
|
作者：
Christian Schultz
Estifanos Ghebremedhin
Heiko Braak
Eva Braak
机构：
[1] Department of Morphology,
[2] Johann Wolfgang Goethe University,undefined
[3] D-60590 Frankfurt/Main,undefined
[4] Germany,undefined
[5] Department of Anatomy,undefined
[6] Johann Wolfgang Goethe University,undefined
[7] Theodor-Stern-Kai 7,undefined
[8] D-60590 Frankfurt/Main,undefined
[9] Germany Tel.: 49-69-6301-6912; Fax: 49-69-6301-6425; e-mail: Schultz@em.uni-frankfurt.de,undefined
来源：
Acta Neuropathologica | 1997年 / 94卷
关键词：
Key words Sex difference; Hypothalamus; Paraventricular nucleus; Supraoptic nucleus; Neurofibrillary changes;
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学科分类号：
摘要：
Severe neurofibrillary changes were identified in the paraventricular and supraoptic nuclei of elderly individuals using markers for Alzheimer’s disease-related intraneuronal pathology. This neurofibrillary pathology is remarkable in that the magnocellular paraventricular and supraoptic nuclei are particularly resistant to Alzheimer’s disease. Moreover, the changes were observed even in non-demented controls, indicating that they develop independently of Alzheimer’s disease. The alterations in the paraventricular and supraoptic nuclei were consistently accompanied by neurofibrillary changes in the mediobasal hypothalamus.
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页码：99 / 102
页数：3
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