Antioxidant and lipid lowering activities of Indian black tea

被引:12
|
作者
Chander R. [1 ,3 ]
Khanna A.K. [1 ]
Raj K. [2 ]
Rastogi A.K. [1 ]
机构
[1] Division of Biochemistry, Central Drug Research Institute
[2] Division of Medicinal Chemistry, Central Drug Research Institute
[3] Division of Biochemistry, CDRI
关键词
Antioxidant activity; Free radicals; Indian Black Tea; Low density lipoprotein oxidation; Triton models;
D O I
10.1007/BF02893063
中图分类号
学科分类号
摘要
Indian black tea; CTC leaf and dust, produced by Tata Tea Limited, Kolkata, (India) was studied in vitro as potential scavenger of oxygen free radicals. Super oxide anions were generated in a system containing xanthine - xanthine oxidase (enzymic system) and by NADH- phenozine methosulphate (non enzymic system). Anions were assayed in terms of uric acid formation and reduction of nitroblue tetrazolium salt, which were shown to be suppressed by tea extracts. Extracts from both leaf and dust also inhibted the formation of hydroxyl radicals in vitro in the enzymic system comprising hypoxanthine - Cu +2 -sodium ascorbate and xanthine oxidase and in non enzymic system of deoxyribose -Cu+2 -sodium ascorbate and H2O2 as well as the Cu+2 induced lipid peroxidation in human low density lipoprotein. Feeding with black tea in normal rats for sixty days increased their antioxidant activity and their liver microsomes were shown to be protected against peroxidation of lipids as stimulated by metal ions with enzymic or non enzymic reactants. Furthermore feeding with tea extracts in normal as well as triton WR -1339 induced hyperlipidemic rats caused decrease in their plasma levels of total cholesterol, phospholipids and triglycerides. The antioxidant and lipid lowering activities of both extracts from CTC leaf and dust tea was comparable and may be due to the presence of natural products like catechin and others.
引用
收藏
页码:153 / 159
页数:6
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