Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

被引：0
|
作者：
Lars M. Ittner
Jürgen Götz
机构：
[1] Lars M. Ittner and Jürgen Götz are at the Alzheimer's and Parkinson's Disease Laboratory,
[2] Brain and Mind Research Institute,undefined
[3] The University of Sydney,undefined
[4] Camperdown,undefined
[5] 100 Mallett Street,undefined
[6] NSW 2050,undefined
[7] Australia.,undefined
来源：
Nature Reviews Neuroscience | 2011年 / 12卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Amyloid-β and tau exert toxicity in Alzheimer's disease through mechanisms that are gradually becoming understood. This Progress article reviews recent findings regarding their possible interactions and synergistic effects at the synapse, and discusses how these effects may contribute to the pathogenesis of Alzheimer's disease.
引用
收藏
页码：67 / 72
页数：5
相关论文
共 50 条
  • [41] Synergistic associations of amyloid-β and phosphorylated tau with tau aggregation and cognitive decline in Alzheimer's disease
    Zhang, Chunhua
    Tai, Yaojun
    Kong, Min
    Jia, Pengyuan
    Ma, Guozhao
    Ba, Maowen
    JOURNAL OF ALZHEIMERS DISEASE, 2025,
  • [42] Changes in the Expression of Genes Associated with Intraneuronal Amyloid-β and Tau in Alzheimer's Disease
    Fujimura, Robert K.
    Reiner, Teresita
    Ma, Fangchao
    Phillips, Virginia
    de las Pozas, Alicia
    Dickson, Dennis W.
    Roos, Bernard A.
    Howard, Guy A.
    Perez-Stable, Carlos
    JOURNAL OF ALZHEIMERS DISEASE, 2010, 19 (01) : 97 - 109
  • [43] Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease
    Baek, Min Seok
    Cho, Hanna
    Lee, Hye Sun
    Lee, Jae Hoon
    Ryu, Young Hoon
    Lyoo, Chul Hyoung
    ALZHEIMERS RESEARCH & THERAPY, 2020, 12 (01)
  • [44] Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease
    Min Seok Baek
    Hanna Cho
    Hye Sun Lee
    Jae Hoon Lee
    Young Hoon Ryu
    Chul Hyoung Lyoo
    Alzheimer's Research & Therapy, 12
  • [45] Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer's disease
    Pereira, Joana B.
    Janelidze, Shorena
    Ossenkoppele, Rik
    Kvartsberg, Hlin
    Brinkmalm, Ann
    Mattsson-Carlgren, Niklas
    Stomrud, Erik
    Smith, Ruben
    Zetterberg, Henrik
    Blennow, Kaj
    Hansson, Oskar
    BRAIN, 2021, 144 : 310 - 324
  • [46] Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimer's Disease
    Silva, D. F. F.
    Esteves, A. R.
    Oliveira, C. R.
    Cardoso, S. M.
    CURRENT ALZHEIMER RESEARCH, 2011, 8 (05) : 563 - 572
  • [47] Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease
    Emma Gerrits
    Nieske Brouwer
    Susanne M. Kooistra
    Maya E. Woodbury
    Yannick Vermeiren
    Mirjam Lambourne
    Jan Mulder
    Markus Kummer
    Thomas Möller
    Knut Biber
    Wilfred F. A. den Dunnen
    Peter P. De Deyn
    Bart J. L. Eggen
    Erik W. G. M. Boddeke
    Acta Neuropathologica, 2021, 141 : 681 - 696
  • [48] Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease
    Gerrits, E.
    Brouwer, N.
    Kooistra, S. M.
    Woodbury, M. E.
    Vermeiren, Y.
    Lambourne, M.
    Mulder, J.
    Kummer, M.
    Moller, T.
    Biber, K.
    den Dunnen, W. F.
    de Deyn, P. P.
    Eggen, B. J.
    Boddeke, E. W.
    GLIA, 2021, 69 : E264 - E265
  • [49] Glucocorticoids increase amyloid-β and tau pathology in a mouse model of Alzheimer's disease
    Green, Kim N.
    Billings, Lauren M.
    Roozendaal, Benno
    McGaugh, James L.
    LaFerla, Frank M.
    JOURNAL OF NEUROSCIENCE, 2006, 26 (35): : 9047 - 9056
  • [50] Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer's disease
    Pereira, Joana B.
    Janelidze, Shorena
    Smith, Ruben
    Mattsson-Carlgren, Niklas
    Palmqvist, Sebastian
    Teunissen, Charlotte E.
    Zetterberg, Henrik
    Stomrud, Erik
    Ashton, Nicholas J.
    Blennow, Kaj
    Hansson, Oskar
    BRAIN, 2021, 144 : 3505 - 3516
12345