Wild-type huntingtin plays a role in brain development and neuronal survival

被引:0
|
作者
Anton Reiner
Ioannis Dragatsis
Scott Zeitlin
Daniel Goldowitz
机构
[1] The University of Tennessee,Department of Anatomy and Neurobiology
[2] The Health Science Center,Department of Physiology, College of Medicine
[3] The University of Tennessee,Department of Neuroscience
[4] The Health Science Center,undefined
[5] University of Virginia School of Medicine,undefined
来源
Molecular Neurobiology | 2003年 / 28卷
关键词
Basal ganglia; cortex; development; Huntington’s Disease; HD gene; colonization;
D O I
暂无
中图分类号
学科分类号
摘要
While the role of the mutated Huntington’s disease (HD) protein in the pathogenesis of HD has been the focus of intensive investigation, the normal protein has received less attention. Nonetheless, the wild-type HD protein appears to be essential for embryogenesis, since deletion of the HD gene in mice results in early embryonic lethality. This early lethality is due to a critical role the HD protein, called huntingtin (Htt), plays in extraembryonic membrane function, presumably in vesicular transport of nutrients. Studies of mutant mice expressing low levels of Htt and of chimeric mice generated by blastocyst injection of Hdh-/- embryonic stem cells show that wild-type Htt plays an important role later in development as well, specifically in forebrain formation. Moreover, various lines of study suggest that normal Htt is also critical for survival of neurons in the adult forebrain.
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页码:259 / 275
页数:16
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