Multicentric Castleman’s disease presenting with multiple nodes in lungs: a case report and literature review

We report a rare multicentric Castleman’s disease case whose lung manifestation is severe than any known report. This is a 64-year-old woman, she had repeated cough, fever and breathlessness for more than 1 year. CT imaging showed multiple small nodules in both the lungs at the first onset. Large nodes and masses in both the lungs evolved 1 year later. After three times of lung biopsies (one video-assisted thoracoscopic surgery and two CT-guided percutaneous transthoracic), she was finally diagnosed as multicentric Castleman’s disease. She got surprising relief after combination chemotherapy in spite of her severe lung changes.