Stereoselective synthesis and alkylation of N-methylmorpholinium 4,5-trans-4-(2-chlorophenyl)-3-cyano-6-hydroxy- 5-(2-thenoyl)-6-trifluoromethyl- 1,4,5,6-tetrahydropyridine-2-thiolate. Molecular and crystal structure of 4,5-trans-4-(2-chlorophenyl)-3-cyano- 6-hydroxy-2-methallylthio-5-(2-thenoyl)- 6-trifluoromethyl-1,4,5,6-tetrahydropyridine

被引：0

作者：

Krivokolysko S.G. ^{[1
]}

Dyachenko V.D. ^{[1
]}

Chernega A.N. ^{[2
]}

Litvinov V.P. ^{[3
]}

机构：

[1] Taras Shevchenko Lugansk State Pedagogical University

[2] Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev

[3] N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow

来源：

Chemistry of Heterocyclic Compounds | 2001年 / Springer Science and Business Media, LLC卷 / 37期

关键词：

2-chlorobenzaldehyde; 2-thenoyltrifluoroacetone; Alkylation; Condensation; Cyanothioacetamide; Tetrahydropyridines;

D O I：

10.1023/A:1013889208646

中图分类号：

学科分类号：

摘要：

The condensation of 2-chlorobenzaldehyde with cyanothioacetamide and 2-thenoyltrifluoroacetone in the presence of N-methylmorpholine takes place stereoselectively and leads to the formation of N-methylmorpholinium 4,5-trans-4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thenoyl) -6-trifluoromethyl-1,4,5,6-tetrahydropyridine-2-thiolate. The latter was used to synthesize the corresponding 2-alkylthiotetrahydropyridines. The structure of 4,5-trans-4-(2-chlorophenyl)-3-cyano-6-hydroxy-2- methallylthio-5-(2-thenoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine was determined by X-ray crystallographic analysis.

引用

页码：1208 / 1215

页数：7

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