Voltammetric Determination of Tinidazole Using a Glassy Carbon Electrode Modified with Single-Wall Carbon Nanotubes

An electrochemical method based on a single-wall carbon nanotubes (SWNTs) film-coated glassy carbon electrode (GCE) was described for the determination of tinidazole. In a 0.1 M Britton-Robinson buffer with a pH of 10.0, tinidazole yields a very sensitive and well-defined reduction peak at -0.78 V (vs. SCE) on a SWNTs-modified GCE. Compared with that on a bare GCE, the reduction peak of tinidazole increases significantly on the modified GCE. Thus, all of the experimental parameters were optimized and a sensitive voltammetric method is proposed for tinidazole determination. It is found that the reduction peak current is proportional to the concentration of tinidazole over the range from 5 × 10-8 to 4 × 10-5 M, and that the detection limit is 1 × 10-8 M at 3 min open-circuit accumulation. This new analysis method was demonstrated with tinidazole drugs.