Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

被引：0

作者：

Chunyu Liu

Aldi T Kraja

Jennifer A Smith

Jennifer A Brody

Nora Franceschini

Joshua C Bis

Kenneth Rice

Alanna C Morrison

Yingchang Lu

Stefan Weiss

Xiuqing Guo

Walter Palmas

Lisa W Martin

Yii-Der Ida Chen

Praveen Surendran

Fotios Drenos

James P Cook

Paul L Auer

Audrey Y Chu

Ayush Giri

Wei Zhao

Johanna Jakobsdottir

Li-An Lin

Jeanette M Stafford

Najaf Amin

Hao Mei

Jie Yao

Arend Voorman

Martin G Larson

Megan L Grove

Albert V Smith

Shih-Jen Hwang

Han Chen

Tianxiao Huan

Gulum Kosova

Nathan O Stitziel

Sekar Kathiresan

Nilesh Samani

Heribert Schunkert

Panos Deloukas

Man Li

Christian Fuchsberger

Cristian Pattaro

Mathias Gorski

Charles Kooperberg

George J Papanicolaou

Jacques E Rossouw

Jessica D Faul

Sharon L R Kardia

Claude Bouchard

机构：

[1] Framingham Heart Study,Department of Biostatistics

[2] National Heart,Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology

[3] Lung,Department of Epidemiology

[4] and Blood Institute,Department of Medicine

[5] School of Public Health,Department of Biostatistics

[6] Boston University,Los Angeles Biomedical Research Institute and Department of Pediatrics

[7] Population Sciences Branch,Division of General Medicine

[8] National Heart,Department of Public Health and Primary Care

[9] Lung,Department of Biostatistics

[10] and Blood Institute,Department of Health Sciences

[11] Washington University School of Medicine,Division of Preventive Medicine

[12] School of Public Health,Division of Public Health Sciences, Department of Biostatistical Sciences

[13] University of Michigan,Department of Epidemiology

[14] Cardiovascular Health Research Unit,Department of Data Science

[15] University of Washington,Department of Mathematics and Statistics

[16] Gillings School of Global Public Health,Department of Biostatistics

[17] University of North Carolina at Chapel Hill,Division of Cardiology, Department of Medicine and Department of Genetics

[18] University of Washington,Department of Cardiovascular Sciences

[19] Human Genetics Center,Department of Epidemiology

[20] School of Public Health,Department of Genetic Epidemiology

[21] University of Texas Health Science Center at Houston,Division of Public Health Sciences

[22] Charles Bronfman Institute for Personalized Medicine,Division of Cardiovascular Sciences

[23] Icahn School of Medicine at Mount Sinai,Department of Epidemiology

[24] DZHK (German Center for Cardiovascular Research),Department of Internal Medicine

[25] partner site Greifswald,Department of Preventive Medicine

[26] Interfaculty Institute for Genetics and Functional Genomics,Department of Medicine

[27] University Medicine and Ernst Moritz Arndt University Greifswald,Cardiovascular Division

[28] Institute for Translational Genomics and Population Sciences,Department of Medicine

[29] Harbor-UCLA Medical Center,Department of Human Genetics

[30] Columbia University Medical Center,Department of Internal Medicine

[31] George Washington University School of Medicine and Health Sciences,Department of Internal Medicine B

[32] Cardiovascular Epidemiology Unit,Department of Medical Research

[33] University of Cambridge,Division of Endocrinology and Metabolism, Department of Internal Medicine

[34] Centre for Cardiovascular Genetics,Department of Obstetrics and Gynecology

[35] Institute of Cardiovascular Science,Department of Medicine

[36] University College London,Department of Epidemiology

[37] MRC Integrative Epidemiology Unit,Department of Medicine

[38] School of Social and Community Medicine,Los Angeles Biomedical Research Institute and Department of Medicine

[39] University of Bristol,Department of Health Services

[40] Oakfield House,undefined

[41] Oakfield Grove,undefined

[42] University of Liverpool,undefined

[43] University of Leicester,undefined

[44] Joseph J. Zilber School of Public Health,undefined

[45] University of Wisconsin–Milwaukee,undefined

[46] Brigham and Women's Hospital,undefined

[47] Vanderbilt Epidemiology Center,undefined

[48] Vanderbilt Genetics Institute,undefined

[49] Institute for Medicine and Public Health,undefined

[50] Vanderbilt University Medical Center,undefined

来源：

Nature Genetics | 2016年 / 48卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Daniel Chasman, Daniel Levy, Christopher Newton-Cheh, Georg Ehret and colleagues perform an association meta-analysis for blood pressure in ∼330,000 individuals and identify 31 new risk loci, implicating biological pathways related to vascular function and cardiometabolic traits. Their findings highlight potential therapeutic strategies for hypertension, emphasizing a link with cardiometabolic risk.

引用

页码：1162 / 1170

页数：8

共 50 条

[11] 87 RARE VARIANTS ASSOCIATED WITH BLOOD PRESSURE IN META-ANALYSIS OF ∼1.32 MILLION INDIVIDUALS
Feofanova, Elena
JOURNAL OF HYPERTENSION, 2021, 39 : E70 - E70
[12] Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
Mateus H. Gouveia
Amy R. Bentley
Hampton Leonard
Karlijn A. C. Meeks
Kenneth Ekoru
Guanjie Chen
Michael A. Nalls
Eleanor M. Simonsick
Eduardo Tarazona-Santos
Maria Fernanda Lima-Costa
Adebowale Adeyemo
Daniel Shriner
Charles N. Rotimi
Scientific Reports, 11
[13] Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits
Gouveia, Mateus H.
Bentley, Amy R.
Leonard, Hampton
Meeks, Karlijn A. C.
Ekoru, Kenneth
Chen, Guanjie
Nalls, Michael A.
Simonsick, Eleanor M.
Tarazona-Santos, Eduardo
Lima-Costa, Maria Fernanda
Adeyemo, Adebowale
Shriner, Daniel
Rotimi, Charles N.
SCIENTIFIC REPORTS, 2021, 11 (01)
[14] Meta-analysis for rare variants
Hannah Stower
Nature Reviews Genetics, 2013, 14 (9) : 596 - 596
[15] Transethnic meta-analysis of exome-wide variants identifies new loci associated with male-specific metabolic syndrome
Lee, Ho-Sun
Kim, Boram
Park, Taesung
GENES & GENOMICS, 2022, 44 (05) : 629 - 636
[16] Transethnic meta-analysis of exome-wide variants identifies new loci associated with male-specific metabolic syndrome
Ho-Sun Lee
Boram Kim
Taesung Park
Genes & Genomics, 2022, 44 : 629 - 636
[17] Common and Rare Sequence Variants Influencing Tumor Biomarkers in Blood
Olafsson, Sigurgeir
Alexandersson, Kristjan F.
Gizurarson, Johann G. K.
Hauksdottir, Katrin
Gunnarsson, Orvar
Olafsson, Karl
Gudmundsson, Julius
Stacey, Simon N.
Sveinbjornsson, Gardar
Saemundsdottir, Jona
Bjornsson, Einar S.
Olafsson, Sigurdur
Bjornsson, Sigurdur
Orvar, Kjartan B.
Vikingsson, Arnor
Geirsson, Arni J.
Arinbjarnarson, Sturla
Bjornsdottir, Gyda
Thorgeirsson, Thorgeir E.
Sigurdsson, Snaevar
Halldorsson, Gisli H.
Magnusson, Olafur T.
Masson, Gisli
Holm, Hilma
Jonsdottir, Ingileif
Sigurdardottir, Olof
Eyjolfsson, Gudmundur I.
Olafsson, Isleifur
Sulem, Patrick
Thorsteinsdottir, Unnur
Jonsson, Thorvaldur
Rafnar, Thorunn
Gudbjartsson, Daniel F.
Stefansson, Kari
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2020, 29 (01) : 225 - 235
[18] Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Feofanova, E. V.
EUROPEAN JOURNAL OF HUMAN GENETICS, 2020, 28 (SUPPL 1) : 118 - 119
[19] Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Praveen Surendran
Elena V. Feofanova
Najim Lahrouchi
Ioanna Ntalla
Savita Karthikeyan
James Cook
Lingyan Chen
Borbala Mifsud
Chen Yao
Aldi T. Kraja
James H. Cartwright
Jacklyn N. Hellwege
Ayush Giri
Vinicius Tragante
Gudmar Thorleifsson
Dajiang J. Liu
Bram P. Prins
Isobel D. Stewart
Claudia P. Cabrera
James M. Eales
Artur Akbarov
Paul L. Auer
Lawrence F. Bielak
Joshua C. Bis
Vickie S. Braithwaite
Jennifer A. Brody
E. Warwick Daw
Helen R. Warren
Fotios Drenos
Sune Fallgaard Nielsen
Jessica D. Faul
Eric B. Fauman
Cristiano Fava
Teresa Ferreira
Christopher N. Foley
Nora Franceschini
He Gao
Olga Giannakopoulou
Franco Giulianini
Daniel F. Gudbjartsson
Xiuqing Guo
Sarah E. Harris
Aki S. Havulinna
Anna Helgadottir
Jennifer E. Huffman
Shih-Jen Hwang
Stavroula Kanoni
Jukka Kontto
Martin G. Larson
Ruifang Li-Gao
Nature Genetics, 2020, 52 : 1314 - 1332
[20] Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran, Praveen
Feofanova, Elena, V
Lahrouchi, Najim
Ntalla, Ioanna
Karthikeyan, Savita
Cook, James
Chen, Lingyan
Mifsud, Borbala
Yao, Chen
Kraja, Aldi T.
Cartwright, James H.
Hellwege, Jacklyn N.
Giri, Ayush
Tragante, Vinicius
Thorleifsson, Gudmar
Liu, Dajiang J.
Prins, Bram P.
Stewart, Isobel D.
Cabrera, Claudia P.
Eales, James M.
Akbarov, Artur
Auer, Paul L.
Bielak, Lawrence F.
Bis, Joshua C.
Braithwaite, Vickie S.
Brody, Jennifer A.
Daw, E. Warwick
Warren, Helen R.
Drenos, Fotios
Nielsen, Sune Fallgaard
Faul, Jessica D.
Fauman, Eric B.
Fava, Cristiano
Ferreira, Teresa
Foley, Christopher N.
Franceschini, Nora
Gao, He
Giannakopoulou, Olga
Giulianini, Franco
Gudbjartsson, Daniel F.
Guo, Xiuqing
Harris, Sarah E.
Havulinna, Aki S.
Helgadottir, Anna
Huffman, Jennifer E.
Hwang, Shih-Jen
Kanoni, Stavroula
Kontto, Jukka
Larson, Martin G.
Li-Gao, Ruifang
NATURE GENETICS, 2020, 52 (12) : 1314 - 1332

← 1 2 3 4 5 →