SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

被引：0
|
作者：
Constanze Schneider
Thomas Oellerich
Hanna-Mari Baldauf
Sarah-Marie Schwarz
Dominique Thomas
Robert Flick
Hanibal Bohnenberger
Lars Kaderali
Lena Stegmann
Anjali Cremer
Margarethe Martin
Julian Lohmeyer
Martin Michaelis
Veit Hornung
Christoph Schliemann
Wolfgang E Berdel
Wolfgang Hartmann
Eva Wardelmann
Federico Comoglio
Martin-Leo Hansmann
Alexander F Yakunin
Gerd Geisslinger
Philipp Ströbel
Nerea Ferreirós
Hubert Serve
Oliver T Keppler
Jindrich Cinatl
机构：
[1] Institute of Medical Virology,Department of Medicine II
[2] University of Frankfurt,Cambridge University Department of Haematology
[3] Hematology and Oncology,Department of Virology
[4] ,Department of Chemical Engineering and Applied Chemistry
[5] Goethe University of Frankfurt,Gene Center and Department of Biochemistry
[6] Cambridge Institute of Medical Research,Department of Medicine A (Hematology
[7] German Cancer Consortium partner site,undefined
[8] German Cancer Research Center,undefined
[9] Max von Pettenkofer Institute,undefined
[10] Ludwig Maximilian University of Munich,undefined
[11] Pharmazentrum frankfurt/ZAFES,undefined
[12] ,undefined
[13] Institute of Clinical Pharmacology,undefined
[14] Goethe University of Frankfurt,undefined
[15] University of Toronto,undefined
[16] Institute of Pathology,undefined
[17] University Medical Center,undefined
[18] Institute of Bioinformatics,undefined
[19] University Medicine Greifswald,undefined
[20] Centre for Molecular Processing and School of Biosciences,undefined
[21] University of Kent,undefined
[22] Institute of Molecular Medicine,undefined
[23] University Hospital Bonn,undefined
[24] Ludwig Maximilian University of Munich,undefined
[25] Oncology),undefined
[26] University Hospital Münster,undefined
[27] Gerhard Domagk Institute for Pathology,undefined
[28] University Hospital Münster,undefined
[29] Senckenberg Institute of Pathology,undefined
[30] University of Frankfurt,undefined
[31] Fraunhofer Institute for Molecular Biology and Applied Ecology (IME),undefined
[32] Project Group Translational Medicine and Pharmacology (TMP),undefined
来源：
Nature Medicine | 2017年 / 23卷
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学科分类号：
摘要：
The therapeutic response of acute myeloid leukemia to the nucleoside analog Ara-C is controlled by SAMHD1, an enzyme that hydrolyzes the active metabolite Ara-CTP.
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页码：250 / 255
页数：5
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