LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration

被引:0
|
作者
Jong Min Hong
Jin-Woo Lee
Dong-Seung Seen
Jae-Yeon Jeong
Won-Ki Huh
机构
[1] Seoul National University,School of Biological Sciences
[2] GPCR Therapeutics Inc,Institute of Microbiology
[3] Seoul National University,undefined
关键词
Chemokine receptor 4; Lysophosphatidic acid receptor 1; G protein-coupled receptor; GPCR heteromer; GPCR signaling; Chemotaxis; Cancer; Inflammatory disease;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Inhibition of CXCR4/CXCL12 signaling: a translational perspective for Alzheimer's disease treatment
    Yuval Gavriel
    Inna Rabinovich-Nikitin
    Beka Solomon
    Neural Regeneration Research, 2022, 17 (01) : 108 - 109
  • [22] LncRNA MALAT1 silencing represses CXCL12-induced proliferation, invasion, and homing behavior in multiple myeloma by inhibiting CXCR4
    Ning, Jing
    Yang, Rui
    Wang, Hainan
    Ma, Hui
    Cui, Lijuan
    HEMATOLOGY, 2024, 29 (01)
  • [23] CXCL12/SDF-1 and CXCR4
    Nagasawa, Takashi
    FRONTIERS IN IMMUNOLOGY, 2015, 6
  • [24] Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis
    Carbajal, Kevin S.
    Schaumburg, Christopher
    Strieter, Robert
    Kane, Joy
    Lane, Thomas E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (24) : 11068 - 11073
  • [25] Sphingomyelin Depletion Inhibits CXCR4 Dynamics and CXCL12-Mediated Directed Cell Migration in Human T Cells
    Gardeta, Sofia R.
    Garcia-Cuesta, Eva M.
    D'Agostino, Gianluca
    Soler Palacios, Blanca
    Quijada-Freire, Adriana
    Lucas, Pilar
    Bernardino de la Serna, Jorge
    Gonzalez-Riano, Carolina
    Barbas, Coral
    Rodriguez-Frade, Jose Miguel
    Mellado, Mario
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [26] Effect of the LPA-mediated CXCL12-CXCR4 axis in the tumor proliferation, migration and invasion of ovarian cancer cell lines
    Wang, Hui
    Liu, Wenli
    Wei, Dongmin
    Hu, Kun
    Wu, Xiaohua
    Yao, Yuanqing
    ONCOLOGY LETTERS, 2014, 7 (05) : 1581 - 1585
  • [27] Role of CXCL12/CXCR4 signaling axis in pancreatic cancer
    WU Peng-fei
    LU Zi-peng
    CAI Bao-bao
    TIAN Lei
    ZOU Chen
    JIANG Kui-rong
    MIAO Yi
    中华医学杂志(英文版), 2013, 126 (17) : 3371 - 3374
  • [28] Role of CXCL12/CXCR4 signaling axis in pancreatic cancer
    Wu Peng-fei
    Lu Zi-peng
    Cai Bao-bao
    Tian Lei
    Zou Chen
    Jiang Kui-rong
    Miao Yi
    CHINESE MEDICAL JOURNAL, 2013, 126 (17) : 3371 - 3374
  • [29] Glioma cell motility is modulated by CXCL12/CXCR4
    Matias, D.
    Carmo, A.
    Lopes, M. C.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S23 - S23
  • [30] Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma
    Im, K. S.
    Graef, A. J.
    Breen, M.
    Lindblad-Toh, K.
    Modiano, J. F.
    Kim, J. -H.
    VETERINARY AND COMPARATIVE ONCOLOGY, 2017, 15 (02) : 315 - 327