Micronization of arbutine using supercritical anti-solvent

被引:0
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作者
Chan Ik Park
Moon Sam Shin
Hwayong Kim
机构
[1] Seoul National University,School of Chemical and Biological Engineering and Institute of Chemical Processes
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关键词
Arbutine; ASES; Supercritical; Anti-solvent;
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摘要
Arbutine has been used as skin whitening agent in cosmetics and pharmaceuticals. The objective of this study was to precipitate arbutine micro-particles using a supercritical anti-solvent. Ethanol and supercritical CO2 were used as solvent and anti-solvent, respectively, under various conditions. The effects of pressure, temperature and solution flow rate on the particles were studied. The particle size and morphology were analyzed by field emission scanning electron microscopy.
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页码:581 / 584
页数:3
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