Type I interferon dysregulation and neurological disease

被引：0
|
作者：
Sarah McGlasson
Alexa Jury
Andrew Jackson
David Hunt
机构：
[1] MRC Human Genetics Unit,
[2] MRC Institute of Genetics and Molecular Medicine,undefined
[3] University of Edinburgh,undefined
来源：
Nature Reviews Neurology | 2015年 / 11卷
关键词：
D O I：
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学科分类号：
摘要：
Type I interferon is an essential component of the innate immune system, which protects the brain against viral infectionUnderactivity of the type I interferon pathway causes predisposition to herpes simplex encephalitisOveractivity of the type I interferon pathway results in a spectrum of Mendelian neuroinflammatory diseases known as 'interferonopathies'Dysregulation of the type I interferon response has an important role in the pathogenesis of more common diseases that can affect the brain, including lupus and cerebrovascular diseaseAberrant activation of the type I interferon pathway offers potential as a useful biomarker and a target for therapy
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页码：515 / 523
页数：8
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