High prevalence of the CYP2B6 516G→T(*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe

被引：0
|
作者：
Christopher Nyakutira
Daniel Röshammar
Emmanuel Chigutsa
Prosper Chonzi
Michael Ashton
Charles Nhachi
Collen Masimirembwa
机构：
[1] African Institute of Biomedical Science and Technology (AiBST),Department of DMPK & BAC
[2] University of Zimbabwe,Department of Clinical Pharmacology, School of Health Sciences
[3] Sahlgrenska Academy at Göteborg University,Department of Pharmacology
[4] University of Zimbabwe,School of Pharmacy
[5] Harare City Council Health Services,undefined
来源：
European Journal of Clinical Pharmacology | 2008年 / 64卷
关键词：
Efavirenz; HIV/AIDS patients; CYP2B6 polymorphism; Pharmacokinetic modelling; NONMEM;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：357 / 365
页数：8
相关论文
共 50 条
  • [41] The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes Lessons from Botswana
    Maseng, Monkgomotsi J.
    Tawe, Leabaneng
    Thami, Prisca K.
    Moyo, Sikhulile
    Kasvosve, Ishmael
    Novitsky, Vladimir
    Essex, Max
    Russo, Gianluca
    Gaseitsiwe, Simani
    Paganotti, Giacomo M.
    MEDICINE, 2022, 101 (17) : E29066
  • [42] Plasma efavirenz concentrations and the association with CYP2B6-516G>T polymorphism in HIV-infected Thai children
    Puthanakit, Thanyawee
    Tanpaiboon, Pranoot
    Aurpibul, Linda
    Cressey, Tim R.
    Sirisanthana, Virat
    ANTIVIRAL THERAPY, 2009, 14 (03) : 315 - 320
  • [43] Cytochrome P450 CYP2B6 genotypes and haplotypes in a Colombian population: identification of novel variant CYP2B6 alleles
    Gonzalo Restrepo, Juan
    Martinez, Carmen
    Garcia-Agundez, Augusto
    Gaviria, Elmer
    Julio Laguna, Jose
    Garcia-Martin, Elena
    Agundez, Jose A. G.
    PHARMACOGENETICS AND GENOMICS, 2011, 21 (12): : 773 - 778
  • [44] THE EFFECT OF WOOHWANGCHEONGSIMWON SUSPENSION ON THE PHARMACOKINETICS OF BUPROPION, A SUBSTRATE OF CYP2B6
    Kim, H.
    Park, S.
    Shim, E.
    Kim, H.
    Shon, J.
    Bae, S.
    Liu, K.
    Shin, J.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 85 : S53 - S54
  • [45] CYP2B6*6 and CYP2B6*18 Predict Long-Term Efavirenz Exposure Measured in Hair Samples in HIV-Positive South African Women
    Roehrich, Carola R.
    Droegemoeller, Britt I.
    Ikediobi, Ogechi
    van der Merwe, Lize
    Grobbelaar, Nelis
    Wright, Galen E. B.
    McGregor, Nathaniel
    Warnich, Louise
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2016, 32 (06) : 529 - 538
  • [46] High efavirenz serum concentrations in TB/HIV-coinfected Ugandan adults with a CYP2B6 516 TT genotype on anti-TB treatment
    von Braun, Amrei
    Castelnuovo, Barbara
    Ledergerber, Bruno
    Cusato, Jessica
    Buzibye, Allan
    Kambugu, Andrew
    Fehr, Jan
    Calcagno, Andrea
    Lamorde, Mohammed
    Sekaggya-Wiltshire, Christine
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019, 74 (01) : 135 - 138
  • [47] Effects of clopidogrel and the CYP2B6*6 allele on the metabolism and pharmacokinetics of efavirenz in healthy male Korean subjects.
    Jiang, F.
    Desta, Z.
    Kim, H.
    Yeo, C.
    Shon, J.
    Liu, K.
    Lee, S.
    Flockhart, D. A.
    Shin, J.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 : S19 - S19
  • [48] High predictive value of CYP2B6 SNPs for steady-state plasma efavirenz levels in South African HIV/AIDS patients
    Swart, Marelize
    Skelton, Michelle
    Ren, Yuan
    Smith, Peter
    Takuva, Simbabrashe
    Dandara, Collet
    PHARMACOGENETICS AND GENOMICS, 2013, 23 (08): : 415 - 427
  • [49] Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz:: the effect of gender, race, and CYP2B6 polymorphism
    Burger, D
    van der Heiden, I
    la Porte, C
    van der Ende, M
    Groeneveld, P
    Richter, C
    Koopmans, P
    Kroon, F
    Sprenger, H
    Lindemans, J
    Schenk, P
    van Schaik, R
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 61 (02) : 148 - 154
  • [50] Effect of CYP2B6, ABCB1, and CYP3A5 Polymorphisms on Efavirenz Pharmacokinetics and Treatment Response: An AIDS Clinical Trials Group Study
    Ribaudo, Heather J.
    Liu, Huan
    Schwab, Matthias
    Schaeffeler, Elke
    Eichelbaum, Michel
    Motsinger-Reif, Alison A.
    Ritchie, Marylyn D.
    Zanger, Ulrich M.
    Acosta, Edward P.
    Morse, Gene D.
    Gulick, Roy M.
    Robbins, Gregory K.
    Clifford, David
    Haas, David W.
    JOURNAL OF INFECTIOUS DISEASES, 2010, 202 (05): : 717 - 722
12345