Reactions of 4-tosyl-2-phenyl-5-chloro-1,3-thiazole with N-, O-, and S-nucleophiles

被引：0

作者：

K. V. Turov

T. K. Vinogradova

V. S. Brovarets

B. S. Drach

机构：

[1] National Academy of Sciences of Ukraine,Institute of Bioorganic Chemistry and Petrochemistry

来源：

Russian Journal of General Chemistry | 2010年 / 80卷

关键词：

EtOH; NaSH; Tosylates; Thiophenol; Thiazole Ring;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The accessible two-center electrophilic substrate 4-tosyl-2-phenyl-5-chloro-1,3-thiazole reacts regioselectively with N-, O-, and S-nucleophiles to eliminate a chloride ion. The analog of this substrate, 4-tosyl-2-phenyl-5-p-chlorophenylsulphonyl-1,3-thiazole, reacts with “soft” and “hard” nucleophiles differently: with the participation of C5 or C4 center, respectively, that seems to be caused by the principle of “symbiosis” in the transition state.

引用

页码：825 / 828

页数：3

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