Reactions of 4-tosyl-2-phenyl-5-chloro-1,3-thiazole with N-, O-, and S-nucleophiles

被引：0
|
作者：
K. V. Turov
T. K. Vinogradova
V. S. Brovarets
B. S. Drach
机构：
[1] National Academy of Sciences of Ukraine,Institute of Bioorganic Chemistry and Petrochemistry
来源：
Russian Journal of General Chemistry | 2010年 / 80卷
关键词：
EtOH; NaSH; Tosylates; Thiophenol; Thiazole Ring;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The accessible two-center electrophilic substrate 4-tosyl-2-phenyl-5-chloro-1,3-thiazole reacts regioselectively with N-, O-, and S-nucleophiles to eliminate a chloride ion. The analog of this substrate, 4-tosyl-2-phenyl-5-p-chlorophenylsulphonyl-1,3-thiazole, reacts with “soft” and “hard” nucleophiles differently: with the participation of C5 or C4 center, respectively, that seems to be caused by the principle of “symbiosis” in the transition state.
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页码：825 / 828
页数：3
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