Therapy Insight: CNS manifestations of HIV-associated immune reconstitution inflammatory syndrome

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作者
David J Riedel
Carlos A Pardo
Justin McArthur
Avindra Nath
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[1] University of Maryland,
[2] Johns Hopkins University,undefined
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The development of combination antiretroviral therapy has led to dramatic reductions in HIV-related morbidity and mortality. Paradoxically, however, the rapid restoration of the immune system that ensues from this treatment can lead to a deterioration in the patient's clinical status—a condition known as immune reconstitution inflammatory syndrome (IRIS). In this Review, Riedel et al. describe the CNS manifestations of IRIS, and they propose a series of guidelines for establishing a diagnosis and managing the condition.
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页码:557 / 565
页数:8
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