Bacterial resistance to arsenic protects against protist killing

被引:0
|
作者
Xiuli Hao
Xuanji Li
Chandan Pal
Jon Hobman
D. G. Joakim Larsson
Quaiser Saquib
Hend A. Alwathnani
Barry P. Rosen
Yong-Guan Zhu
Christopher Rensing
机构
[1] Chinese Academy of Sciences,Key Laboratory of Urban Environment and Health, Institute of Urban Environment
[2] University of Copenhagen,Department of Biology
[3] University of Gothenburg,Department of Infectious Diseases, Institute for Biomedicine, Sahlgrenska Academy
[4] Center for Antibiotic Resistance Research (CARe) at the University of Gothenburg,School of Biosciences
[5] The University of Nottingham,Zoology Department, College of Science
[6] King Saud University,A.R. Al
[7] King Saud University,Jeraisy Chair for DNA Research, Zoology Department, College of Science
[8] King Saud University,Botany & Microbiology Department, College of Science
[9] Florida International University,Herbert Wertheim College of Medicine
[10] J. Craig Venter Institute,Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation, College of Resources and Environment
[11] Fujian Agriculture and Forestry University,undefined
来源
BioMetals | 2017年 / 30卷
关键词
Protist; Grazing; Arsenic;
D O I
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中图分类号
学科分类号
摘要
Protists kill their bacterial prey using toxic metals such as copper. Here we hypothesize that the metalloid arsenic has a similar role. To test this hypothesis, we examined intracellular survival of Escherichia coli (E. coli) in the amoeba Dictyostelium discoideum (D. discoideum). Deletion of the E. coli ars operon led to significantly lower intracellular survival compared to wild type E. coli. This suggests that protists use arsenic to poison bacterial cells in the phagosome, similar to their use of copper. In response to copper and arsenic poisoning by protists, there is selection for acquisition of arsenic and copper resistance genes in the bacterial prey to avoid killing. In agreement with this hypothesis, both copper and arsenic resistance determinants are widespread in many bacterial taxa and environments, and they are often found together on plasmids. A role for heavy metals and arsenic in the ancient predator–prey relationship between protists and bacteria could explain the widespread presence of metal resistance determinants in pristine environments.
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页码:307 / 311
页数:4
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