PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment

被引：0
|
作者：
Linhua Jin
Yoko Tabe
Kensuke Kojima
Masato Shikami
Juliana Benito
Vivian Ruvolo
Rui-Yu Wang
Teresa McQueen
Stefan O. Ciurea
Takashi Miida
Michael Andreeff
Marina Konopleva
机构：
[1] Juntendo University School of Medicine,Department of Clinical Laboratory Medicine
[2] The University of Texas MD Anderson Cancer Center,Department of Leukemia
[3] Aichi Medical University,Department of Hematology
[4] The University of Texas MD Anderson Cancer Center,Department of Stem Cell Transplantation and Cellular Therapy
来源：
Journal of Molecular Medicine | 2013年 / 91卷
关键词：
Acute myeloid leukemia; Bone marrow microenvironment; Hypoxia; Apoptosis; GDC-0941; ABT-737;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1383 / 1397
页数：14
相关论文
共 50 条
  • [1] PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment
    Jin, Linhua
    Tabe, Yoko
    Kojima, Kensuke
    Shikami, Masato
    Benito, Juliana
    Ruvolo, Vivian
    Wang, Rui-Yu
    McQueen, Teresa
    Ciurea, Stefan O.
    Miida, Takashi
    Andreeff, Michael
    Konopleva, Marina
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2013, 91 (12): : 1383 - 1397
  • [2] Efficacy and Mechanisms of Apoptosis Induction by Simultaneous Inhibition of PI3K with GDC-0941 and Blockade of Bcl-2 (ABT-737) or FLT3 (Sorafenib) In AML Cells In the Hypoxic Bone Marrow Microenvironment
    Jin, Linhua
    Tabe, Yoko
    Zhou, Yixin
    Miida, Takashi
    Andreeff, Michael
    Konopleva, Marina
    BLOOD, 2010, 116 (21) : 341 - 341
  • [3] GDC-0941 and ABT-737 cooperate to sensitize isolated mitochondria from PI3K mutant cells
    Buron, N.
    Porceddu, M.
    Disley, D.
    Torrance, C.
    Borgne-Sanchez, A.
    EJC SUPPLEMENTS, 2010, 8 (07): : 47 - 47
  • [4] Ellagic Acid Enhances the Efficacy of PI3K Inhibitor GDC-0941 in Breast Cancer Cells
    Shi, L.
    Gao, X.
    Li, X.
    Jiang, N.
    Luo, F.
    Gu, C.
    Chen, M.
    Cheng, H.
    Liu, P.
    CURRENT MOLECULAR MEDICINE, 2015, 15 (05) : 478 - 486
  • [5] PI3K Signaling Pathway Activation Predicts Class I PI3K Inhibitor GDC-0941 Sensitivity in AML.
    Ma, Xiaoju Max
    Du, Changchun
    Sun, Laura
    Shi, Xiaoyan
    Friedman, Lori
    Doman, David
    Ebens, Allen J.
    BLOOD, 2009, 114 (22) : 437 - 437
  • [6] Radiosensitisation properties of PI3K/AKT inhibitor GDC-0941 in prostate cancer cells
    Floyd, R.
    McDermott, N.
    Meunier, A.
    Marignol, L.
    RADIOTHERAPY AND ONCOLOGY, 2015, 115 : S572 - S572
  • [7] THE PI3K INHIBITOR GDC-0941 ENHANCES RADIOSENSITIZATION AND REDUCES CHEMORESISTANCE TO TEMOZOLOMIDE IN GBM CELL LINES
    Shi, Fei
    Guo, Hongchuan
    Zhang, Rong
    Liu, Hongyu
    Wu, Liangliang
    Wu, Qiyan
    Liu, Jialin
    Liu, Tianyi
    Zhang, Qiuhang
    NEUROSCIENCE, 2017, 346 : 298 - 308
  • [8] GDC-0941 PI3K inhibitor activity in preclinical lung cancer models
    Friedman, L.
    Belvin, M.
    Berry, L.
    Haverty, P.
    Hoeflich, K.
    Lackner, M.
    Sampath, D.
    Wallin, J.
    Yauch, B.
    EJC SUPPLEMENTS, 2010, 8 (07): : 51 - 51
  • [9] The PI3K Inhibitor GDC-0941 Induces Growth Arrest and Apoptosis of Acute Myeloid Leukemia Cells
    Sun, Laura
    Berry, Leanne
    Du, Changchun
    Ma, Xiaoju Max
    Shi, Lily
    Medeiros, Bruno C.
    Ebens, Allen J.
    BLOOD, 2009, 114 (22) : 1456 - 1456
  • [10] Mechanisms of acquired resistance to the PI3K inhibitor GDC-0941 in breast cancer cell lines
    Edgar, Kyle A.
    Hwu, Ling
    Walter, Kimberly
    Lackner, Mark
    Friedman, Lori S.
    Wallin, Jeffrey J.
    MOLECULAR CANCER THERAPEUTICS, 2015, 14 (07)
12345