Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways

被引：0
|
作者：
Bin Wu
Rong Wang
Shengnan Li
Yuanyuan Wang
Fuxing Song
Yanqiu Gu
Yongfang Yuan
机构：
[1] Shanghai Jiao Tong University School of Medicine,Department of Pharmacy, Shanghai 9th People’s Hospital
来源：
Pharmacological Reports | 2019年 / 71卷
关键词：
Liver fibrosis; Fraxetin; NF-κB; MAPKs; Inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：409 / 416
页数：7
相关论文
共 50 条
  • [41] Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-κB, Bax/Bcl-2 and PI3K/Akt/mTOR signaling pathways
    Kucukler, Sefa
    Caglayan, Cuneyt
    Darendelioglu, Ekrem
    Kandemir, Fatih Mehmet
    LIFE SCIENCES, 2020, 261
  • [42] Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A
    Mohan, Syam
    Abdelwahab, Siddig Ibrahim
    Kamalidehghan, Behnam
    Syam, Suvitha
    May, Koh Sue
    Harmal, Nabil Saad Mohammed
    Shafifiyaz, Noor
    Hadi, A. Hamid A.
    Hashim, Najihah Mohd
    Rahmani, Mawardi
    Taha, Manal Mohamed Elhassan
    Cheah, Shiau-Chuen
    Zajmi, Asdren
    PHYTOMEDICINE, 2012, 19 (11) : 1007 - 1015
  • [43] Targeting BCL-2 overexpression in various human malignancies through NF-κB inhibition by the proteasome inhibitor bortezomib
    Bridget N. Fahy
    Michael G. Schlieman
    Melinda M. Mortenson
    Subbulakshmi Virudachalam
    Richard J. Bold
    Cancer Chemotherapy and Pharmacology, 2005, 56 : 46 - 54
  • [44] Targeting BCL-2 overexpression in various human malignancies through NF-κB inhibition by the proteasome inhibitor bortezomib
    Fahy, BN
    Schlieman, MG
    Mortenson, MM
    Virudachalam, S
    Bold, RJ
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2005, 56 (01) : 46 - 54
  • [45] Exploring the cardioprotective effects of canagliflozin against cisplatin-induced cardiotoxicity: Role of iNOS/NF-κB, Nrf2, and Bax/cytochrome C/Bcl-2 signals
    Ali, Fares E. M.
    Hassanein, Emad H. M.
    Abd El-Ghafar, Omnia A. M.
    Rashwan, Eman K.
    Saleh, Fayez M.
    Atwa, Ahmed M.
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023, 37 (04)
  • [46] Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression
    Awad, Azza Sayed
    Elariny, Hemat A.
    Sallam, Amany Said
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2022, 100 (01) : 12 - 18
  • [47] Zafirlukast protects against hepatic ischemia-reperfusion injury in rats via modulating Bcl-2/Bax and NF-κB/SMAD-4 pathways
    Mahmoud, Heba M.
    Abouzed, Deiaa E. Elsayed
    Abo-youssef, Amira M.
    Hemeida, Ramadan A. M.
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 122
  • [48] Enzymatic-extractable polysaccharides from Cordyceps militaris alleviate carbon tetrachloride-induced liver injury via Nrf2/ROS/NF-ΚB signaling pathway
    Zhao, Huajie
    Deng, Baoguo
    Li, Duan
    Jia, Le
    Yang, Fan
    JOURNAL OF FUNCTIONAL FOODS, 2022, 95
  • [49] The Effect of Nimesulide on the Expression of NF-κB,Bcl-2 and Bax in the Human Gastric Cancer SGC-7901 Cell Line
    Zu’an Zhu1 Ying Liu2 Tao Cui2 Sujuan Fei31 Department of Radiotherapy
    Chinese Journal of Clinical Oncology, 2006, (03) : 196 - 201
  • [50] Amygdalin attenuates PM2.5-induced human umbilical vein endothelial cell injury via the TLR4/NF-κB and Bcl-2/Bax signaling pathways
    Wang, Bixu
    Sun, Tong
    Sun, Ling
    Li, Lan
    Wan, Haitong
    Ding, Zhishan
    Ye, Xiaoqing
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2022, 54 (10) : 1476 - 1485
12345