Telomerase inhibitors as novel antitumor drugs

被引：0
|
作者：
A. I. Glukhov
L. V. Svinareva
S. E. Severin
V. I. Shvets
机构：
[1] Sechenov Medical Academy,
[2] Moscow Research Institute of Medical Ecology,undefined
[3] Lomonosov Moscow State Academy of Fine Chemical Technology,undefined
来源：
Applied Biochemistry and Microbiology | 2011年 / 47卷
关键词：
antisense therapy; immortalization; G-quadruplex; ribozyme; RNA interference; telomerase activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Telomerase activity is detected in most types of human tumors, but it is almost undetectable in normal somatic cells; therefore, telomerase is a promising therapeutic target. The present review describes various approaches to telomerase inhibition, namely, antisense therapy, RNA interference, and the use of ribozymes and agents interacting with the telomeric G-quadruplex. The use of these compounds in clinical research is analyzed in the review.
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收藏
页码：655 / 660
页数：5
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