The Interactive Effects of Age and PICALM rs541458 Polymorphism on Cognitive Performance, Brain Structure, and Function in Non-demented Elderly

被引:0
|
作者
Zhen Liu
Xiangwei Dai
Junying Zhang
Xin Li
Yaojing Chen
Chao Ma
Kewei Chen
Dantao Peng
Zhanjun Zhang
机构
[1] Beijing Normal University,State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research
[2] Beijing Normal University,BABRI Centre
[3] Banner Alzheimer’s Institute,Department of Neurology
[4] China-Japan Friendship Hospital,undefined
来源
Molecular Neurobiology | 2018年 / 55卷
关键词
Alzheimer’s disease; Executive function; Functional connectivity; Gray matter volume;
D O I
暂无
中图分类号
学科分类号
摘要
The PICALM rs541458 T allele has been recognized as a risk factor for late-onset Alzheimer’s disease, and age might modulate the effects that genetic factors have on cognitive functions and brain. Thus, the current study intended to examine whether the effects of rs541458 on cognitive functions, brain structure, and function were modulated by age in non-demented Chinese elderly. We enrolled 638 subjects aged 50 to 82 years and evaluated their cognitive functions through a series of neuropsychological tests. Seventy-eight of these participants also received T1-weighted structural and resting state functional magnetic resonance imaging. Dividing subjects into groups <65 and ≥65 years old, results of neuropsychological tests showed that interactive effects of rs541458 × age existed with regard to executive function and processing speed after controlling for gender, years of education and APOE ε4 status. In addition, the effects of rs541458 on resting state functional connectivity of left superior parietal gyrus within left frontal-parietal network and on gray matter volume of left middle temporal gyrus were modulated by age. Furthermore, reduction of functional connectivity of left superior parietal gyrus was closely related with better executive function in the T allele carriers <65 years old. Further, greater volume of left middle temporal gyrus was significantly related to better executive function in both CC genotype <65 years old and CC genotype ≥65 years old groups, separately. Pending further confirmation from additional studies, our results support the hypothesis that the modulation of age, with respect to the rs541458, has interactional effects on cognitive performance, brain function, and structural measurements.
引用
收藏
页码:1271 / 1283
页数:12
相关论文
共 37 条
  • [21] Brain microstructural changes and cognitive function in non-demented essential tremor patients: a diffusion tensor imaging study
    Sengul, Y.
    Temur, H. O.
    Corakci, Z.
    Sengul, H. S.
    Dowd, H.
    Ustun, I.
    Alkan, A.
    Louis, E. D.
    INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2021, 132 (02) : 154 - 164
  • [22] Plasma BDNF Is Associated with Age-Related White Matter Atrophy but Not with Cognitive Function in Older, Non-Demented Adults
    Driscoll, Ira
    Martin, Bronwen
    An, Yang
    Maudsley, Stuart
    Ferrucci, Luigi
    Mattson, Mark P.
    Resnick, Susan M.
    PLOS ONE, 2012, 7 (04):
  • [23] Differential Effect of Demographics, Processing Speed, and Depression on Cognitive Function in 755 Non-demented Community-dwelling Elderly Individuals
    Mougias, Antonios
    Christidi, Foteini
    Synetou, Margarita
    Kotrotsou, Irene
    Valkimadi, Polena
    Politis, Antonios
    COGNITIVE AND BEHAVIORAL NEUROLOGY, 2019, 32 (04) : 236 - 246
  • [24] Salivary cortisol and five-year change in cognitive performance in non-demented elderly subjects: a population-based study
    Ouanes, Sami
    Castelao, Enrique
    von Gunten, Armin
    Kuehner, Christine
    Preisig, Martin
    Popp, Julius
    NEUROBIOLOGY OF AGING, 2020, 94 : 34 - 37
  • [25] APOE ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly
    Sun, Jinping
    Zhu, Zhibao
    Chen, Kewei
    Wei, Dongfeng
    Li, Xin
    Li, He
    Zhang, Junying
    Chen, Xiaochun
    Chen, Yaojing
    Zhang, Zhanjun
    AGING-US, 2020, 12 (12): : 12019 - 12031
  • [26] The relation between sleep breathing disorder (SDB) and cognitive decline in non-demented elderly is influenced by age: Findings form the Cretan Aging Cohort
    Basta, Maria
    Alexopoulou, Christina
    Skourti, Eleni
    Ganiaris, Andronikos
    Zampetakis, Alexandros
    Zaganas, Ioannis
    Simos, Panagiotis
    Vgontzas, Alexandros
    JOURNAL OF SLEEP RESEARCH, 2024, 33
  • [27] Olfactory identification in non-demented elderly population and in mild cognitive impairment: a comparison of performance in clinical odor identification versus Boston Naming Test
    Laakso, Mikko P.
    Tervo, Susanna
    Hanninen, Tuomo
    Vanhanen, Matti
    Hallikainen, Merja
    Soininen, Hilkka
    JOURNAL OF NEURAL TRANSMISSION, 2009, 116 (07) : 891 - 895
  • [28] Longitudinal MRI brain volume changes in non-demented 60-90-year-olds: The associations of age, gender and memory performance
    Budge, MM
    Bradley, K
    Smith, S
    de Jager, C
    Smith, AD
    Chen, J
    NEUROBIOLOGY OF AGING, 2002, 23 (01) : S367 - S367
  • [29] Olfactory identification in non-demented elderly population and in mild cognitive impairment: a comparison of performance in clinical odor identification versus Boston Naming Test
    Mikko P. Laakso
    Susanna Tervo
    Tuomo Hänninen
    Matti Vanhanen
    Merja Hallikainen
    Hilkka Soininen
    Journal of Neural Transmission, 2009, 116 : 891 - 895
  • [30] Effects of smartphone application-based cognitive training at home on cognition in community-dwelling non-demented elderly individuals: A randomized controlled trial
    Jang, Hyemin
    Yeo, Minyoung
    Cho, Jinju
    Kim, Seonwoo
    Chin, Juhee
    Kim, Hee Jin
    Seo, Sang Won
    Na, Duk L.
    ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, 2021, 7 (01)