Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomas

被引:0
|
作者
Aurélie Kamoun
Ahmed Idbaih
Caroline Dehais
Nabila Elarouci
Catherine Carpentier
Eric Letouzé
Carole Colin
Karima Mokhtari
Anne Jouvet
Emmanuelle Uro-Coste
Nadine Martin-Duverneuil
Marc Sanson
Jean-Yves Delattre
Dominique Figarella-Branger
Aurélien de Reyniès
François Ducray
机构
[1] Programme Cartes d’Identité des Tumeurs (CIT),Département de Pathologie et Neuropathologie
[2] Ligue Nationale Contre Le Cancer,Department of Cancer Cell Plasticity
[3] Université Pierre et Marie Curie Paris 6,Pathology Department
[4] Centre de Recherche de l’Institut de Cerveau et de la Moelle Epinière (CRICM),Pathology Department
[5] UMR 975,Pathology Department
[6] INSERM U975,Neurosurgery Department
[7] CNRS,Neuro
[8] UMR 7225,oncology Department
[9] AP-HP,Neuropathology Department
[10] Groupe Hospitalier Pitié-Salpêtrière,Pathology Department
[11] Service de Neurologie 2-Mazarin,Medical Oncology Department
[12] Université de la Méditerranée,Neurology Department
[13] Aix-Marseille,Medical Oncology Department
[14] Faculté de Médecine La Timone,Neurosurgery Department
[15] CRO2,Pathology Department
[16] UMR 911,Pathology Department
[17] AP-HP,Neuro
[18] Groupe Hospitalier Pitié-Salpêtrière,oncology Department
[19] Laboratoire de Neuropathologie R. Escourolle,Radiotherapy Department
[20] Hôpital Neurologique,Radiotherapy Department
[21] Hospices Civils de Lyon,Neurosurgery Department
[22] CHU Toulouse,Neurosurgery Department
[23] Hôpital de Rangueil,Neurosurgery Department
[24] Service d’Anatomie et Cytologie Pathologique,Radiotherapy Department
[25] AP-HP,Pathology Department
[26] Groupe Hospitalier Pitié-Salpêtrière,Pathology Department
[27] Service de Neuroradiologie,Neurosurgery Department
[28] Onconeurotek,Radiotherapy Department
[29] Groupe Hospitalier Pitié-Salpêtrière,Neurosurgery Department
[30] AP-HM,Neurosurgery Department
[31] Hôpital de la Timone,Pathology Department
[32] Service d’Anatomie Pathologique et de Neuropathologie,Neurology Department
[33] Hospices Civils de Lyon,Neurosurgery Department
[34] Hôpital Neurologique,Neurosurgery Department
[35] Service de Neuro-Oncologie,Neurology Department
[36] Cancer Research Centre of Lyon,Neurosurgery Department
[37] INSERM U1052,Neuro
[38] CNRS UMR5286,oncology Department
[39] Université Claude Bernard Lyon 1,Pathology Department
[40] Hôpital Bicêtre,Neurosurgery Department
[41] CHU Saint-Pierre de la Réunion,Pathology Department
[42] CHU Dijon,Neurosurgery Department
[43] CHU de Montpellier,Pathology Department
[44] CHU Nancy,Neurology Department
[45] Groupe Hospitalier Pitié-Salpêtrière,Pathology Department
[46] CHR Orléans,Neurosurgery Department
[47] Centre René Gauducheau,Neurosurgery Department
[48] Hôpital Avicenne,Neurosurgery Department
[49] Clinique des Cèdres,Pathology Department
[50] Hôpital Beaujon,Pathology Department
来源
Nature Communications | / 7卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups are currently distinguished on the basis of the IDH mutation and 1p/19q co-deletion. Here we present an integrated analysis of the transcriptome, genome and methylome of 156 OT. Not only does our multi-omics classification match the current classification but also reveals three subgroups within 1p/19q co-deleted tumours, associated with specific expression patterns of nervous system cell types: oligodendrocyte, oligodendrocyte precursor cell (OPC) and neuronal lineage. We confirm the validity of these three subgroups using public datasets. Importantly, the OPC-like group is associated with more aggressive clinical and molecular patterns, including MYC activation. We show that the MYC activation occurs through various alterations, including MYC genomic gain, MAX genomic loss, MYC hypomethylation and microRNA-34b/c down-regulation. In the lower grade glioma TCGA dataset, the OPC-like group is associated with a poorer outcome independently of histological grade. Our study reveals previously unrecognized heterogeneity among 1p/19q co-deleted tumours.
引用
收藏
相关论文
共 50 条
  • [31] Eighty percent survival rate at 15 years for 1p/19q co-deleted oligodendroglioma treated with upfront chemotherapy irrespective of tumor grade
    Yasuo Iwadate
    Tomoo Matsutani
    Ayaka Hara
    Seiichiro Hirono
    Shiro Ikegami
    Masayoshi Kobayashi
    Daisuke Ito
    Daisuke Kawauchi
    Kentaro Horiguchi
    Ado Tamiya
    Yoshinori Higuchi
    Journal of Neuro-Oncology, 2019, 141 : 205 - 211
  • [32] Eighty percent survival rate at 15 years for 1p/19q co-deleted oligodendroglioma treated with upfront chemotherapy irrespective of tumor grade
    Iwadate, Yasuo
    Matsutani, Tomoo
    Hara, Ayaka
    Hirono, Seiichiro
    Ikegami, Shiro
    Kobayashi, Masayoshi
    Ito, Daisuke
    Kawauchi, Daisuke
    Horiguchi, Kentaro
    Tamiya, Ado
    Higuchi, Yoshinori
    JOURNAL OF NEURO-ONCOLOGY, 2019, 141 (01) : 205 - 211
  • [33] Comparison of FISH and NGS Based 1p/19q Co-Deletion in Gliomas
    Stougaard, M.
    Johnsen, L. O.
    Thomsen, R.
    Holm, K.
    Jakobsen, A. -K.
    Franch, O.
    Knudsen, B. R.
    Riber-Hansen, R.
    Steiniche, T.
    Ulhoi, B. P.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2019, 21 (03): : S55 - S55
  • [34] 1p/19q Co-Deletion and Polysomy in Oligodendroglial Tumors - A Single Institution Study
    Chen, H.
    Stewart, C.
    Marc, R.
    Jason, H.
    Lu, W.
    Suresh, J.
    Khedoudja, N.
    Meera, H.
    MODERN PATHOLOGY, 2013, 26 : 415A - 415A
  • [35] 1p/19q Co-Deletion and Polysomy in Oligodendroglial Tumors - A Single Institution Study
    Chen, H.
    Stewart, C.
    Marc, R.
    Jason, H.
    Lu, W.
    Suresh, J.
    Khedoudja, N.
    Meera, H.
    LABORATORY INVESTIGATION, 2013, 93 : 415A - 415A
  • [36] Identification of a novel population in high-grade oligodendroglial tumors not deleted on 1p/19q using array CGH
    Matthieu Talagas
    Pascale Marcorelles
    Arnaud Uguen
    Sylvia Redon
    Isabelle Quintin-Roué
    Sebastian Costa
    Claude Férec
    Frédéric Morel
    Phong Dam Hieu
    Marc De Braekeleer
    Journal of Neuro-Oncology, 2012, 109 : 405 - 413
  • [37] Identification of a novel population in high-grade oligodendroglial tumors not deleted on 1p/19q using array CGH
    Talagas, Matthieu
    Marcorelles, Pascale
    Uguen, Arnaud
    Redon, Sylvia
    Quintin-Roue, Isabelle
    Costa, Sebastian
    Ferec, Claude
    Morel, Frederic
    Phong Dam Hieu
    De Braekeleer, Marc
    JOURNAL OF NEURO-ONCOLOGY, 2012, 109 (02) : 405 - 413
  • [38] Multiplex ligation-dependent probe amplification (MLPA) in the diagnosis of 1p/19q deletions in oligodendroglial tumours
    Grobler, M.
    Vast, M.
    Elderfield, K.
    Butler, S.
    Marks, K.
    Taylor, R.
    Bridges, L. R.
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2011, 37 : 16 - 17
  • [39] 1P, 19Q, 9P AND 10Q CHROMOSOMAL DELETIONS: THE IMPLICATIONS ON TREATMENT RESPONSE IN PROGRESSED OLIGODENDROGLIAL TUMOURS
    Campbell, B.
    Horsman, D.
    Maguire, J.
    Young, S.
    Curman, D.
    Ma, R.
    Thiessen, B.
    RADIOTHERAPY AND ONCOLOGY, 2008, 88 : S38 - S38
  • [40] Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma
    Zhao, Binghao
    Ma, Wenbin
    LANCET ONCOLOGY, 2021, 22 (08): : E345 - E345