Theiler’s murine encephalomyelitis virus infection of astrocytes induces the expression of chemokines which attract activated but not resting T lymphocytes

被引：0

作者：

Nazario Rubio

Francisco Sanz-Rodriguez

机构：

[1] Instituto Cajal. C.S.I.C,Department of Biology

[2] Universidad Autonoma de Madrid,undefined

来源：

Journal of NeuroVirology | 2019年 / 25卷

关键词：

Chemokines; CXCL9/Mig; Astrocytes; T lymphocytes; Neuroinflammation; Multiple sclerosis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In this article, we studied the production of the chemokine CXCL9, also termed Mig (monokine induced by gamma interferon) by cultured SJL/J mouse astrocytes infected with the BeAn strain of Theiler’s murine encephalomyelitis virus (TMEV). This picornavirus induces demyelination in the SJL/J genetically susceptible strain of mice through an immune process mediated by CD4+ Th1 T cells. Those cells were chemoattracted by chemokines inside the central nervous system (CNS) after blood-brain barrier (BBB) disruption.

引用

页码：844 / 852

页数：8

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