Vulvar and vaginal intraepithelial neoplasia (VIN/VAIN) 3 [Vulväre und vaginale intraepitheliale neoplasie (VIN/VAIN) 3]

被引：0
|
作者：
Jentschke M. [1 ]
Soergel P. [1 ]
Hillemanns P. [1 ]
机构：
[1] Klinik für Frauenheilkunde und Geburtshilfe, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1
来源：
Der Gynäkologe | 2012年 / 45卷 / 4期
关键词：
Human papillomavirus; Imiquimod; Intraepithelial neoplasias; Photodynamic therapy; Vaccination;
D O I：
10.1007/s00129-011-2897-1
中图分类号：
学科分类号：
摘要：
VIN 3 and VAIN 3 are associated with HPV infection of the lower genital tract. Compared to CIN they are much less frequent, but there has been an increase in the incidence of VIN over the last decades. VIN often causes pain and pruritus, while VAIN is asymptomatic in most cases and is diagnosed after abnormal Pap smear. VIN and VAIN are treated similarly. Single lesions can be excised. (Hemi-) vulvectomy or partial vaginectomy is necessary in cases of large or multifocal lesions. Laser vaporization is another effective treatment method. The immune modulator imiquimod is the most popular medical treatment. Recurrence of VIN and VAIN after treatment is not uncommon. Progression to invasive cancer happens in 5-10%. New methods like photodynamic therapy can help to improve the treatment of VIN and VAIN in the future. © Springer-Verlag 2012.
引用
收藏
页码：304 / 308
页数：4
相关论文
共 34 条
  • [21] SKINNING VULVECTOMY AND CONIZATION TOGETHER IN THE TREATMENT OF VULVAR INTRAEPITHELIAL NEOPLASIA (VIN) 3 OF THE VULVA AND HIGH SQUAMOUS INTRAEPITHELIAL NEOPLASIA (HSIL) OF THE UTERINE CERVIX: ORAL PRESENTATION
    Ates, M. C.
    Akar, S.
    Guler, A. H.
    Cintesun, E.
    Ugurluoglu, C.
    Celik, C.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2019, 29 : A599 - A599
  • [22] IMPACT OF HISTOLOGICAL TUMOR-FREE MARGIN (HTFM) AND RE-EXCISION ON SURVIVAL IN PRIMARY VULVAR CANCER WITH ADJACENT VULVAR INTRAEPITHELIAL NEOPLASIA (VIN III)
    Gasimli, K.
    Straussner, M.
    Schmeil, I.
    Becker, S.
    Winkelmann, R.
    Thomas, K.
    El-Balat, A.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2017, 27 : 1847 - 1847
  • [23] Impact of histological tumor-free margin (hTFM) and re-excision on survival in primary vulvar cancer with adjacent vulvar intraepithelial neoplasia (VIN III).
    Gasimli, K.
    Straussner, M.
    Schmeil, I.
    Karn, T.
    Winkelmann, R.
    Becker, S.
    El-Balat, A.
    ONCOLOGY RESEARCH AND TREATMENT, 2018, 41 : 87 - 87
  • [24] IMPACT OF HISTOLOGICAL TUMOR-FREE MARGIN (hTFM) AND RE-EXCISION ON SURVIVAL IN PRIMARY VULVAR CANCER WITH ADJACENT VULVAR INTRAEPITHELIAL NEOPLASIA (VIN III)
    Gasimli, K.
    Straussner, M.
    Schmeil, I.
    Becker, S.
    Winkelmann, R.
    Thomas, K.
    El-Balat, A.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2017, 27 : 347 - 347
  • [25] The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment
    Frega, Antonio
    Sopracordevole, Francesco
    Scirpa, Paolo
    Biamonti, Alberto
    Lorenzon, Laura
    Scarani, Simona
    De Sanctis, Luana
    Pacchiarotti, Arianna
    Moscarini, Massimo
    French, Deborah
    MEDICAL SCIENCE MONITOR, 2011, 17 (09): : CR532 - CR535
  • [26] High-grade vaginal intraepithelial neoplasia (VAIN2/3): comparison of clinical outcomes between treated and untreated patients in an observational cohort study
    Pandey, B.
    Papoutsis, D.
    Guttikonda, S.
    Ritchie, J.
    Reed, N.
    Panikkar, J.
    Blundell, S.
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2015, 122 : 149 - 149
  • [27] Impact of re-excision of residual adjacent vulvar intraepithelial neoplasia (VIN III) and histological tumour-free margin (hTFM) on survival in primary squamous cell carcinoma of vulva
    Khayal Gasimli
    Martina Straussner
    Iryna Schmeil
    Thomas Karn
    Ria Winkelmann
    Sven Becker
    Ahmed El-Balat
    Archives of Gynecology and Obstetrics, 2018, 298 : 945 - 950
  • [28] Impact of re-excision of residual adjacent vulvar intraepithelial neoplasia (VIN III) and histological tumour-free margin (hTFM) on survival in primary squamous cell carcinoma of vulva
    Gasimli, Khayal
    Straussner, Martina
    Schmeil, Iryna
    Karn, Thomas
    Winkelmann, Ria
    Becker, Sven
    El-Balat, Ahmed
    ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2018, 298 (05) : 945 - 950
  • [29] Recurrence of vulval intraepithelial neoplasia following treatment with cidofovir or imiquimod: results from a multicentre, randomised, phase II trial (RT3VIN)
    Hurt, C. N.
    Jones, S. E. F.
    Madden, T-A
    Fiander, A.
    Nordin, A. J.
    Naik, R.
    Powell, N.
    Carucci, M.
    Tristram, A.
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2018, 125 (09) : 1171 - 1177
  • [30] LONG TERM RESULTS FROM RT3VIN: A MULTI-CENTRE, RANDOMISED, PHASE II TRIAL OF CIDOFOVIR OR IMIQUIMOD TREATMENT FOR VULVAL INTRAEPITHELIAL NEOPLASIA 3
    Jones, S.
    Hurt, C.
    Madden, T.
    Fiander, A.
    Nordin, A.
    Naik, R.
    Powell, N.
    Tristram, A.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2017, 27 : 54 - 54
1234