Synthesis of 4,6-bis(1H-1,2,3-triazolyl)pyrimidines by the reaction of 4,6-diazido-2-(4-methoxyphenyl)pyrimidine with compounds containing a reactive methylene group

被引：0
|
作者：
Nikolaenkova E.B. [1 ]
Krivopalov V.P. [1 ]
机构：
[1] Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
来源：
Chemistry of Heterocyclic Compounds | 1997年 / 33卷 / 8期
关键词：
Methylene; Ester; Organic Chemistry; Pyrimidine; Triethylamine;
D O I：
10.1007/BF02253171
中图分类号：
学科分类号：
摘要：
The reaction of 4,6-diazido-2-(4-methoxyphenyl)pyrimidine with cyanoacetic ester in the presence of triethylamine leads only to 4-azido-6-amino-1-(4-methoxyphenyl)pyrimidine. The main product in reactions with 1,3-dicarbonyl compounds (acetylacetone, acetoacetic and benzoylacetic esters) is the corresponding substituted 4,6-bis(1H-1,2,3-triazolyl)pyrimidine. Theformation of4-azido-6-(1H-1,2,3-triazolyl)pyrimidine and4-amino-6-(1H-1,2,3-triazolyl)pyrimidine as minor products was also recorded. ©1998 Plenum Publishing Corporation.
引用
收藏
页码：968 / 972
页数：4
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