Clonal expansions of CD8+ T cells in latently HSV-1-infected human trigeminal ganglia

被引：0
|
作者：
Kathrin Held
Ingrid Eiglmeier
Susanne Himmelein
Inga Sinicina
Thomas Brandt
Diethilde Theil
Klaus Dornmair
Tobias Derfuss
机构：
[1] University of Basel,Department of Neurology/Department of Biomedicine
[2] Ludwig Maximilian University,Institute of Clinical Neuroimmunology
[3] Max-Planck-Institute of Neurobiology,Institute of Neuroimmunology
[4] Ludwig Maximilian University,Department of Clinical Neurosciences
[5] Novartis Institute of Biomedical Research,Department of Legal Medicine
[6] IFB,undefined
[7] Ludwig Maximilian University,undefined
[8] Ludwig Maximilian University,undefined
来源：
Journal of NeuroVirology | 2012年 / 18卷
关键词：
HSV-1; Latency; CD8; T cells; Human; Trigeminal ganglia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor β-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded β-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides.
引用
收藏
页码：62 / 68
页数：6
相关论文
共 50 条
  • [11] PD-L1/B7-H1 Regulates the Survival but Not the Function of CD8+ T Cells in Herpes Simplex Virus Type 1 Latently Infected Trigeminal Ganglia
    Jeon, Sohyun
    St Leger, Anthony J.
    Cherpes, Thomas L.
    Sheridan, Brian S.
    Hendricks, Robert L.
    JOURNAL OF IMMUNOLOGY, 2013, 190 (12): : 6277 - 6286
  • [12] Changes in gene expression in latent HSV-1-infected rabbit trigeminal ganglia following epinephrine iontophoresis
    Kang, SW
    Seo, SK
    Hill, JM
    Kwon, B
    Lee, HW
    Cho, HR
    Vinay, DS
    Kwon, BS
    CURRENT EYE RESEARCH, 2003, 26 (3-4) : 225 - 229
  • [13] Local CD4 and CD8 T-Cell Reactivity to HSV-1 Antigens Documents Broad Viral Protein Expression and Immune Competence in Latently Infected Human Trigeminal Ganglia
    van Velzen, Monique
    Jing, Lichen
    Osterhaus, Albert D. M. E.
    Sette, Alessandro
    Koelle, David M.
    Verjans, Georges M. G. M.
    PLOS PATHOGENS, 2013, 9 (08)
  • [14] Clonal CD8+ T cell expansions in peripheral blood from human immunodeficiency virus type 1-infected children
    McFarland, EJ
    Harding, PA
    Striebich, CC
    MaWhinney, S
    Kuritzkes, DR
    Kotzin, BL
    JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (04): : 477 - 485
  • [15] Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia
    Khanna, KM
    Bonneau, RH
    Kinchington, PR
    Hendricks, RL
    IMMUNITY, 2003, 18 (05) : 593 - 603
  • [16] CD8+ T Cells Play a Bystander Role in Mice Latently Infected with Herpes Simplex Virus 1
    Mott, Kevin R.
    Gate, David
    Matundan, Harry H.
    Ghiasi, Yasamin N.
    Town, Terrence
    Ghiasi, Homayon
    JOURNAL OF VIROLOGY, 2016, 90 (10) : 5059 - 5067
  • [17] Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia
    Verjans, Georges M. G. M.
    Hintzen, Rogier Q.
    van Dun, Jessica M.
    Poot, Angelique
    Milikan, Johannes C.
    Laman, Jon D.
    Langerak, Anton W.
    Kinchington, Paul R.
    Osterhaus, Albert D. M. E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (09) : 3496 - 3501
  • [18] Qa-1b and CD94-NKG2a interaction regulate cytolytic activity of herpes simplex virus-specific memory CD8+ T cells in the latently infected trigeminal ganglia
    Suvas, S
    Azkur, AK
    Rouse, BT
    JOURNAL OF IMMUNOLOGY, 2006, 176 (03): : 1703 - 1711
  • [19] The herpes simplex virus 1 encoded latency associated transcript promotes dysfunctional virus specific CD8+T cells in latently infected trigeminal ganglia
    Chentoufi, Aziz Alami
    Kritzer, Elizabeth
    Tran, Michael
    Dasgupta, Gargi
    Afifi, Rasha
    Jiang, Xianzhi
    Osorio, Nelson
    Carpenter, Dale
    Nesburn, Anthony
    Wechsler, Steven
    BenMohamed, Lbachir
    JOURNAL OF IMMUNOLOGY, 2011, 186
  • [20] Gene expression profiling in the HSV-1 latently infected mouse trigeminal ganglia following hyperthermic stress
    Higaki, S
    Gebhardt, BM
    Lukiw, WJ
    Thompson, HW
    Hill, JM
    CURRENT EYE RESEARCH, 2003, 26 (3-4) : 231 - 238
12345