Short form of the heparin-binding EGF-like growth factor: Communication II

被引：0
|
作者：
E. V. Loukianov
Yu. V. Kozlov
机构：
[1] Russian Academy of Sciences,Engelhardt Institute of Molecular Biology
[2] University of Oslo,Center of Medical Research
来源：
Molecular Biology | 2006年 / 40卷
关键词：
growth factors; HB-EGF; epidermal growth factor; EGF domain; alternative splicing; EGFR;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The structure of the green monkey Chlorocebus aethiops heparin-binding EGF-like growth factor (HB-EGF) gene was compared with that of the corresponding human gene. Exon 3a, characteristic of the short form of HB-EGF (SF-HB-EGF), was mapped between exons 3 and 4, approximately 700 bp away from the latter. In several human and simian cell lines, most of the SF-HB-EGF mRNA proved to lack exons 4 and 5, specific to the HB-EGF mRNA. In contrast to the HB-EGF mRNA, the SF-HB-EGF mRNA occurred predominantly in the P, rather than L, form, which codes for a protein with a different propeptide structure. Labeled SF-HB-EGF competed with HB-EGF and EGF for binding to the surface of A431 cells, suggesting its interaction with the specific EGF receptor. The results indicate that SF-HB-EGF plays a specific role in cell signaling.
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页码：797 / 804
页数：7
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