TRF2 binds branched DNA to safeguard telomere integrity

被引：0
|
作者：
Isabelle Schmutz
Leonid Timashev
Wei Xie
Dinshaw J Patel
Titia de Lange
机构：
[1] Laboratory for Cell Biology and Genetics,
[2] The Rockefeller University,undefined
[3] Structural Biology Program,undefined
[4] Memorial Sloan-Kettering Cancer Center,undefined
来源：
Nature Structural & Molecular Biology | 2017年 / 24卷
关键词：
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暂无
中图分类号：
学科分类号：
摘要：
Functional analysis of TRF2-RuvC chimeras establishes that binding of the TRF2 basic domain to branched-DNA structures of the t-loop is responsible for telomere protection in mouse and human cells.
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页码：734 / 742
页数：8
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