Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas

被引:0
|
作者
Birgitta Lehtinen
Annina Raita
Juha Kesseli
Matti Annala
Kristiina Nordfors
Olli Yli-Harja
Wei Zhang
Tapio Visakorpi
Matti Nykter
Hannu Haapasalo
Kirsi J. Granberg
机构
[1] BioMediTech Institute and Faculty of Medicine and Life Sciences,Department of Pathology
[2] Fimlab Laboratories Ltd.,Department of Pediatrics
[3] Tampere University Hospital,Department of Signal Processing
[4] University of Tampere,Department of Cancer Biology
[5] Tampere University Hospital; Tampere Center for Child Health Research,undefined
[6] University of Tampere,undefined
[7] Tampere University of Technology,undefined
[8] Comprehensive Cancer Center of Wake Forest Baptist Medical Center,undefined
[9] Science Center,undefined
[10] Tampere University Hospital,undefined
来源
BMC Cancer | / 17卷
关键词
Tissue microarray; Deep-sequencing; FGFR inhibition; Immunohistochemistry staining;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation
    Philipp Sievers
    Daniel Schrimpf
    Damian Stichel
    David E. Reuss
    Martin Hasselblatt
    Christian Hagel
    Ori Staszewski
    Jürgen Hench
    Stephan Frank
    Sebastian Brandner
    Andrey Korshunov
    Wolfgang Wick
    Stefan M. Pfister
    Guido Reifenberger
    Andreas von Deimling
    Felix Sahm
    David T. W. Jones
    Acta Neuropathologica, 2020, 139 : 403 - 406
  • [22] FGFR3 MUTATIONS AND THEIR RELATION TO FGFR3 EXPRESSION AND CLINICAL OUTCOME IN A LARGE RADICAL CYSTECTOMY COHORT: IMPLICATIONS FOR ANTI-FGFR3 BLADDER CANCER TREATMENT?
    van Rhijn, Bas
    Mertens, Laura
    Mayr, Roman
    Bostrom, Peter
    Marquez, Mirari
    Zwarthoff, Ellen
    Boormans, Joost
    Abas, Cheno
    van Leenders, Geert
    Gotz, Stefanie
    Bertz, Simone
    Neuzillet, Yann
    Sanders, Joyce
    Broeks, Annegien
    van der Heijden, Michiel
    Jewett, Michael
    Real, Francisco
    Stohr, Robert
    Zlotta, Alexandre
    Eckstein, Markus
    Scoorojebally, Yanish
    Burger, Max
    Otto, Wolfgang
    Radvanyi, Francois
    Sirab, Nanour
    Pouessel, Damien
    van der Kwast, Theo
    Malats, Nuria
    Hartmann, Arndt
    Allory, Yves
    van der Schoot, Deric
    Zuiverloon, Tahlita
    JOURNAL OF UROLOGY, 2019, 201 (04): : E924 - E924
  • [23] Expression and clinical significance of FGFR1 and FGFR2 in laryngeal squamous cell carcinoma
    Hu, Mengdie
    Zhang, Shujun
    TRANSLATIONAL CANCER RESEARCH, 2022, 11 (09) : 3222 - 3234
  • [24] Using immunohistochemistry to evaluate FGFR3 gene fusion recurrence and clinical associations in astrocytomas
    Granberg, Kirsi J.
    Lehtinen, Birgitta
    Annala, Matti J.
    Haapasalo, Hannu
    Nykter, Matti
    Zhang, Wei
    CANCER RESEARCH, 2014, 74 (19)
  • [25] Genetic Inhibition of FGFR1 in Cartilage at Adult stage Attenuates the Degeneration of Articular Cartilage in FGFR3 disruption mice
    Xie, Yangli
    Xu, Wei
    Huang, Junlan
    Du, Xiaolan
    Zhou, Siru
    Chen, Lin
    Wang, Zuqiang
    JOURNAL OF BONE AND MINERAL RESEARCH, 2014, 29 : S81 - S82
  • [26] Fibroblast growth factor receptor 1 (FGFR1) is over-expressed in benign prostatic hyperplasia whereas FGFR2-IIIc and FGFR3 are not
    Boget, S
    Cereser, C
    Parvaz, P
    Leriche, A
    Revol, A
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2001, 145 (03) : 303 - 310
  • [27] DIFFERENTIAL REGULATION OF FIBROBLAST GROWTH FACTOR-3 CONTROLS FGFR1:FGFR3 BALANCE IN CHONDROCYTES AFTER CARTILAGE INJURY
    Khan, S. N.
    Chanalaris, A.
    Vincent, T. L.
    OSTEOARTHRITIS AND CARTILAGE, 2016, 24 : S137 - S137
  • [28] Anti-tumor activity of infigratinib, a potent and selective inhibitor of FGFR1, FGFR2 and FGFR3, in FGFR fusion-positive cholangiocarcinoma and other solid tumors
    Li, Gary
    Krook, Melanie
    Roychowdhury, Sameek
    Avogadri, Francesca
    Ye, Yining
    Moran, Susan
    CANCER RESEARCH, 2019, 79 (13)
  • [29] Novel targetable FGFR2 and FGFR3 alterations in glioblastoma associate with aggressive phenotype and distinct gene expression programs
    Maria-Magdalena Georgescu
    Mohammad Zahidul Islam
    Yan Li
    James Traylor
    Anil Nanda
    Acta Neuropathologica Communications, 9
  • [30] Identification of pathogenic FGFR1, FGFR2, and FGFR3 alterations in cell-free DNA (cfDNA) from patients with metastatic breast cancer
    Taylor, Mary Love
    Mayro, Benjamin
    Drusbosky, Leylah
    Batchelder, Robin
    Marcom, P. Kelly
    Anders, Carey
    Force, Jeremy
    CANCER RESEARCH, 2021, 81 (04)