Manufacturing enterprises face intensive competitive pressures, and many firms are forced to redesign processes just to stay even with the competition. But process redesign is an expensive, time-consuming, and labor-intensive activity, and first-generation computer-based tools are inadequate for redesign today. Alternatively, knowledge-based systems and intelligent tools have the ability to address the key intellectual activities required for effective process redesign. The research described in this article addresses an intelligent redesign tool called KOPeR. The article describes the KOPeR design and implementation and highlights its use and mechanics in the context of a manufacturing supply-chain example. It then turns to application of KOPeR as a redesign tool in the field, through an “industrial-strength” reengineering engagement, to redesign major supply-chain processes. The field results reveal insights into the use, utility, and potential of this tool in procurement, manufacturing, and beyond. The article closes with a number of promising future directions for related research.