Dendritic cell vaccination and immune monitoring

被引：0

作者：

E. H. J. G. Aarntzen

C. G. Figdor

G. J. Adema

C. J. A. Punt

I. J. M. de Vries

机构：

[1] Nijmegen Centre for Molecular Life Sciences,Department of Medical Oncology

[2] Radboud University Nijmegen Medical Centre,Department of Tumor Immunology

[3] Nijmegen Centre for Molecular Life Sciences,Department of Pediatric Hemato

[4] Radboud University Nijmegen Medical Centre,Oncology

[5] Nijmegen Centre for Molecular Life Sciences,undefined

[6] Radboud University Nijmegen Medical Centre,undefined

来源：

Cancer Immunology, Immunotherapy | 2008年 / 57卷

关键词：

Dendritic cells; Specific immune responses; Migration; mRNA transfection; In vivo targeting;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We exploited dendritic cells (DC) to vaccinate melanoma patients. We recently demonstrated a statistical significant correlation between favorable clinical outcome and the presence of vaccine-related tumor antigen-specific T cells in delayed type hypersensitivity (DTH) skin biopsies. However, favorable clinical outcome is only observed in a minority of the treated patients. Therefore, it is obvious that current DC-based protocols need to be improved. For this reason, we study in small proof of principle trials the fate, interactions and effectiveness of the injected DC.

引用

页码：1559 / 1568

页数：9

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