Dendritic cell vaccination and immune monitoring

被引：0
|
作者：
E. H. J. G. Aarntzen
C. G. Figdor
G. J. Adema
C. J. A. Punt
I. J. M. de Vries
机构：
[1] Nijmegen Centre for Molecular Life Sciences,Department of Medical Oncology
[2] Radboud University Nijmegen Medical Centre,Department of Tumor Immunology
[3] Nijmegen Centre for Molecular Life Sciences,Department of Pediatric Hemato
[4] Radboud University Nijmegen Medical Centre,Oncology
[5] Nijmegen Centre for Molecular Life Sciences,undefined
[6] Radboud University Nijmegen Medical Centre,undefined
来源：
Cancer Immunology, Immunotherapy | 2008年 / 57卷
关键词：
Dendritic cells; Specific immune responses; Migration; mRNA transfection; In vivo targeting;
D O I：
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中图分类号：
学科分类号：
摘要：
We exploited dendritic cells (DC) to vaccinate melanoma patients. We recently demonstrated a statistical significant correlation between favorable clinical outcome and the presence of vaccine-related tumor antigen-specific T cells in delayed type hypersensitivity (DTH) skin biopsies. However, favorable clinical outcome is only observed in a minority of the treated patients. Therefore, it is obvious that current DC-based protocols need to be improved. For this reason, we study in small proof of principle trials the fate, interactions and effectiveness of the injected DC.
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页码：1559 / 1568
页数：9
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