The role of NF-κB in 6-hydroxydopamine- and TNFα-induced apoptosis of PC12 cells

被引：0
|
作者：
Victoria Tarabin
Markus Schwaninger
机构：
[1] University of Heidelberg,Department of Neurology
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2004年 / 369卷
关键词：
6-Hydroxydopamine; NF-κB; Gene transcription; Neurodegeneration; Parkinson’s disease; TNFα;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
6-Hydroxydopamine (6-OHDA) is widely used to study the death of catecholaminergic cells related to Parkinson’s disease. Oxidative stress and gene transcription are known to mediate the pro-apoptotic effect of 6-OHDA. As redox mechanisms are involved in activation of the transcription factor NF-κB, we studied the role of NF-κB in 6-OHDA-induced death of PC12 cells.
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页码：563 / 569
页数：6
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