Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice

被引：0
|
作者：
Yunsik Choi
Sanghyuk Lee
Kapyoul Kim
Soo-Hyun Kim
Yeun-Jun Chung
Charles Lee
机构：
[1] Ewha Womans University,Department of Life Sciences
[2] The Catholic University of Korea,Department of Microbiology, Precision Medicine Research Center, IRCGP, College of Medicine
[3] The Jackson Laboratory for Genomic Medicine,undefined
来源：
Experimental & Molecular Medicine | 2018年 / 50卷
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摘要：
Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient’s own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.
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页码：1 / 9
页数：8
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