Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice

被引:0
|
作者
Deepa Mathew
Julia Barillas-Cerritos
Ana Nedeljkovic-Kurepa
Mabel Abraham
Matthew D. Taylor
Clifford S. Deutschman
机构
[1] Cohen Children’s Medical Center,Department of Pediatrics
[2] Institute for Molecular Medicine,undefined
[3] Feinstein Institutes for Medical Research,undefined
[4] Pediatric Endocrinology,undefined
[5] Metabolism and Diabetes,undefined
[6] Zucker School of Medicine at Hofstra/Northwell,undefined
来源
关键词
Sepsis; Cecal ligation and puncture; CLP; Insulin; Insulin receptor substrate; Tyrosine phosphorylation; Hypoglycemia; Insulin resistance; Liver; Skeletal muscle;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers
    Midori Honma
    Shojiro Sawada
    Yoshiyuki Ueno
    Keigo Murakami
    Tetsuya Yamada
    Junhong Gao
    Shinjiro Kodama
    Tomohito Izumi
    Kei Takahashi
    Sohei Tsukita
    Kenji Uno
    Junta Imai
    Eiji Kakazu
    Yasuteru Kondo
    Kei Mizuno
    Naoki Kawagishi
    Tooru Shimosegawa
    Hideki Katagiri
    International Journal of Obesity, 2018, 42 : 1544 - 1555
  • [22] Dual knockdown of IRS-1 and IRS-2 in liver exacerbates insulin resistance to cause diabetes
    Taniguchi, CM
    Ueki, K
    Kahn, CR
    DIABETES, 2005, 54 : A340 - A341
  • [23] IRS-2 differs from IRS-1 in insulin-induced tyrosine phosphorylation and activation of PI 3-kinase.
    Ogihara, T
    Funaki, M
    Katagiri, H
    Oka, Y
    Yazaki, Y
    Asano, T
    DIABETES, 1996, 45 : 435 - 435
  • [24] Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers
    Honma, Midori
    Sawada, Shojiro
    Ueno, Yoshiyuki
    Murakami, Keigo
    Yamada, Tetsuya
    Gao, Junhong
    Kodama, Shinjiro
    Izumi, Tomohito
    Takahashi, Kei
    Tsukita, Sohei
    Uno, Kenji
    Imai, Junta
    Kakazu, Eiji
    Kondo, Yasuteru
    Mizuno, Kei
    Kawagishi, Naoki
    Shimosegawa, Tooru
    Katagiri, Hideki
    INTERNATIONAL JOURNAL OF OBESITY, 2018, 42 (09) : 1544 - 1555
  • [25] Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis
    Gibson, Shannon L.
    Ma, Zhefu
    Shaw, Leslie M.
    CELL CYCLE, 2007, 6 (06) : 631 - 637
  • [26] Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice
    Dominici, FP
    Hauck, S
    Argentino, DP
    Bartke, A
    Turyn, D
    JOURNAL OF ENDOCRINOLOGY, 2002, 173 (01) : 81 - 94
  • [27] Unique Properties of the Insulin Receptor Substrates (IRS)-1 and IRS-2 To Mediate IGF-1 Signaling.
    Emanuelli, B.
    Tseng, Y. H.
    Macotela, Y.
    Kahn, C. R.
    ENDOCRINE REVIEWS, 2010, 31 (03)
  • [28] Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism
    Taniguchi, CM
    Ueki, K
    Kahn, CR
    JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (03): : 718 - 727
  • [29] IRS-1, -3, and -4, but not IRS-2 are novel substrates for PKC-ζ that represent an IRS isoform-specific negative feedback mechanism for insulin signaling
    Lynn, EG
    Kim, JA
    Quon, MJ
    DIABETES, 2005, 54 : A335 - A335
  • [30] Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function
    Paz, K
    Liu, YF
    Shorer, H
    Hemi, R
    LeRoith, D
    Quan, M
    Kanety, H
    Seger, R
    Zick, Y
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (40) : 28816 - 28822