An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives

被引：0
|
作者：
Abdelmounaim Safer
Mustapha Rahmouni
François Carreaux
Ludovic Paquin
Olivier Lozach
Laurent Meijer
Jean Pierre Bazureau
机构：
[1] Université Ibn Khaldoun,Laboratoire de Synthèse et de Catalyse
[2] UMR CNRS 6226,Groupe Ingénierie Chimique et Molécules pour le Vivant (ICMV), Laboratoire Sciences Chimiques de Rennes
[3] CNRS,Protein Phosphorylation and Human Disease, Station Biologique de Roscoff
来源：
Chemical Papers | 2011年 / 65卷
关键词：
rhodanine; isatin; Knoevenagel condensation; solvent-free microwave;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of nine 5-arylidenerhodanine derivatives was prepared in good yields and purity without the use of a solvent or catalyst under microwave-assisted condensation with some substituted isatins. All 5-arylidenerhodanines were evaluated as possible inhibitors of the CK1α/β, CDK5/p25, and GSK-3α/β kinases. None of them showed substantive inhibitory activity against these kinases when evaluated at the concentration of 10 μM.
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页码：332 / 337
页数：5
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