Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes

被引：0

作者：

Rinke Stienstra

Yulia Haim

Yael Riahi

Mihai Netea

Assaf Rudich

Gil Leibowitz

机构：

[1] Radboud University Medical Centre,Department of General Medicine

[2] Wageningen University,Department of Human Nutrition

[3] Inflammation and Immunity (N4i),Nijmegen Institute for Infection

[4] Ben-Gurion University of the Negev,Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences

[5] Hadassah-Hebrew University Medical Center,Endocrinology and Metabolism Service, Department of Medicine

[6] Ben-Gurion University of the Negev,The National Institute of Biotechnology in the Negev (NIBN)

来源：

Diabetologia | 2014年 / 57卷

关键词：

Adipocyte; Adipose tissue; Apoptosis; Autophagy; Beta cell; Diabetes; ER stress; Inflammation; Insulin resistance; Macrophage; Obesity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Autophagy is a lysosomal degradation pathway recycling intracellular long-lived proteins and damaged organelles, thereby maintaining cellular homeostasis. In addition to inflammatory processes, autophagy has been implicated in the regulation of adipose tissue and beta cell functions. In obesity and type 2 diabetes autophagic activity is modulated in a tissue-dependent manner. In this review we discuss the regulation of autophagy in adipose tissue and beta cells, exemplifying tissue-specific dysregulation of autophagy and its implications for the pathophysiology of obesity and type 2 diabetes. We will highlight common themes and outstanding gaps in our understanding, which need to be addressed before autophagy could be envisioned as a therapeutic target for the treatment of obesity and diabetes.

引用

页码：1505 / 1516

页数：11

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