Anti-TNF-alpha loss of response is associated with a decreased percentage of FoxP3+ T cells and a variant NOD2 genotype in patients with Crohn’s disease

被引：0

作者：

Oriol Juanola

Alba Moratalla

Ana Gutiérrez

Laura Sempere

Pedro Zapater

Paula Giménez

Isabel Almenta

Gloria Peiró

José M. González-Navajas

José F. Such

Rubén Francés

机构：

[1] CIBERehd,Servicio de Medicina Digestiva

[2] Instituto de Salud Carlos III,Servicio de Farmacología Clínica

[3] Hospital General Universitario de Alicante,Servicio de Anatomía Patológica

[4] Hospital General Universitario de Alicante,Dpto. Medicina Clínica

[5] Hospital General Universitario de Alicante,Digestive Disease Institute

[6] Universidad Miguel Hernández,undefined

[7] Cleveland Clinic Abu Dhabi,undefined

来源：

Journal of Gastroenterology | 2015年 / 50卷

关键词：

Crohn’s disease; FoxP3+ regulatory T cells; Anti-TNF-alpha;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

页码：758 / 768

页数：10

共 25 条

[21] Expansion of IL-23 receptor bearing TNFR2+T cells is associated with molecular resistance to anti-TNF therapy in Crohn's disease
Schmitt, Heike
Billmeier, Ulrike
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[22] Response to infliximab treatment in Crohn's disease is not associated with mutations in the CARD15 (NOD2) gene:: an analysis in 534 patients from two multicenter, prospective GCP-level trials
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Hampe, J
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[23] Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study
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[24] In Vitro Adalimumab Exposure Decreases RORγT Expressing and RORγT/FoxP3 Double Expressing T-Lymphocytes From Peripheral Blood of Crohn's Disease Patients: A Study of Th17 Plasticity in Response to Anti-TNF
Ueno, Aito
Li, Ji
Hirota, Christina
Jijon, Humberto
Gasia, Miriam Fort
Chan, Ronald
Tom, Michael R.
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GASTROENTEROLOGY, 2015, 148 (04) : S324 - S325
[25] Decreased production of IFN gamma by anti-CD3 stimulated peripheral blood mononuclear cells (PBMC) correlates with the expression of IL-2R alpha (CD25) but not beta (CD122) subunit of IL-2 receptor in healthy: Subjects and in patients with Hodgkin's disease (HD)
Frydecka, I
Mazur, G
Kuliczkowski, K
BRITISH JOURNAL OF HAEMATOLOGY, 1996, 93 : 1106 - 1106

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